I 65 $south, US 35 $east
907.8 mi14 hours 29 mins
| Head southeast on Main Street | 200 feet | |
| Turn left onto 4th Street North (US 53) | 0.4 mi | |
| Go straight onto 3rd Street North (US 53) | 500 feet | |
| Continue onto Copeland Avenue (US 53) | 0.4 mi | |
| Continue onto Rose Street (US 53) | 2.7 mi | |
| Take the ramp on the right onto US 53 N | 42.9 mi | |
| Continue onto I 90 | 97.1 mi | |
| Continue towards I 39:I 90: Chicago | 81.5 mi | |
| Keep left onto Jane Addams Memorial Tollway (I 90) | 40.5 mi | |
| Keep left onto Jane Addams Memorial Tollway (I 90 E) | 1.0 mi | |
| Merge right onto Kennedy Expressway (I 90) | 5.6 mi | |
| Keep right onto Kennedy Expressway (I 90) | 8.3 mi | |
| Continue onto Dan Ryan Expressway (I 90) | 2.4 mi | |
| Keep left towards I 90 Express | 3.8 mi | |
| Take the ramp towards I 90 East: Chicago Skyway | 0.4 mi | |
| Merge right onto Dan Ryan Expressway (I 90) | 0.5 mi | |
| Keep left towards I 90 East: Chicago Skyway | 10.6 mi | |
| Keep left onto Indiana Toll Road (I 90) | 11.3 mi | |
| Take the ramp towards IN 53 | 0.3 mi | |
| Turn right onto Broadway (SR 53) | 0.2 mi | |
| Turn left onto East 5th Avenue (US 12) | 1.6 mi | |
| Turn right onto I 65 S | 132.7 mi | |
| Keep left onto I 65 S | 16.9 mi | |
| Take exit 112A on the left towards I 70 East: Dayton | 0.4 mi | |
| Merge right onto I 70 | 98.5 mi | |
| Take the ramp towards SR 49 South: Clayton | 9.9 mi | |
| Turn right onto West Riverview Avenue | 400 feet | |
| Go straight onto Edwin C. Moses Boulevard | 0.3 mi | |
| Turn left onto West 3rd Street | 0.7 mi | |
| Turn right onto South Ludlow Street (SR 48) | 0.5 mi | |
| Take the ramp | 0.5 mi | |
| Merge left onto US 35 E | 11.7 mi | |
| Keep right towards US 35: Washington Court House | 66.8 mi | |
| Keep left onto US 35 E | 58.6 mi | |
| Keep right onto US 35 E | 0.6 mi | |
| Continue onto Silver Memorial Bridge (US 35 S) | 10.0 mi | |
| Continue onto US 35 | 19.7 mi | |
| Continue onto US 35 S | 6.9 mi | |
| Turn left onto County Route 33 | 100 feet | |
| Turn left onto US 35 N | 400 feet | |
| Take the ramp | 0.5 mi | |
| Merge left onto I 64 E | 118.2 mi | |
| Continue onto I 77 S | 26.5 mi | |
| Keep left towards I 77 South: Roanoke | 7.4 mi | |
| Take the ramp towards US 52 South: Fort Chiswell | 1,000 feet | |
| Turn right onto Fort Chiswell Road (US 52) | 5.2 mi | |
| Turn right onto Austinville Road (SR 619) | 2.5 mi | |
| Turn left onto Store Hill Road (SR 636) | 0.6 mi | |
| You have arrived at your destination |
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La Crosse, Wisconsin - Austinville, Virginia