I 90 $west, US 10 $west
318.3 mi5 hours 30 mins
| Head west on Cameron Avenue | 600 feet | |
| Turn right onto 10th Street South | 400 feet | |
| Turn left onto Cass Street | 0.2 mi | |
| Enter the roundabout and take the 2nd exit onto Cass Street (WI 16) | 200 feet | |
| Exit the roundabout onto Cass Street (WI 16) | 1.7 mi | |
| Continue onto US 14 | 1.7 mi | |
| Turn right | 400 feet | |
| Continue onto US 14 | 2.0 mi | |
| Continue onto US 61 | 0.2 mi | |
| Keep left onto US 61 | 0.6 mi | |
| Merge right onto I 90 W | 4.1 mi | |
| Continue onto I 90 W | 52.7 mi | |
| Take the ramp towards US 52 | 0.3 mi | |
| Keep right at the fork | 1,000 feet | |
| Merge right onto US 52 N | 5.1 mi | |
| Keep left onto US 52 N | 30.2 mi | |
| Continue onto US 52 | 35.5 mi | |
| Take the ramp onto Clayton Avenue (US 52 N) | 0.4 mi | |
| Merge right onto Courthouse Boulevard East (US 52 N) | 3.4 mi | |
| Continue onto US 52 N | 0.5 mi | |
| Keep left onto MN 55 W | 8.6 mi | |
| Continue onto MN 55 N | 0.4 mi | |
| Continue onto MN 55 W | 800 feet | |
| Take the ramp towards MN 55 West: Hiawatha Avenue | 1,000 feet | |
| Keep left at the fork | 700 feet | |
| Turn right onto Hiawatha Avenue | 4.6 mi | |
| Keep left onto Hiawatha Avenue (MN 55) | 0.5 mi | |
| Take the ramp towards I 94 West | 0.8 mi | |
| Merge left onto I 94 W | 8.3 mi | |
| Continue onto I 94 N | 1.7 mi | |
| Continue onto I 94 W | 5.9 mi | |
| Continue onto I 94 N | 17.5 mi | |
| Keep right onto Mainline | 3.0 mi | |
| Merge left onto I 94 N | 18.2 mi | |
| Take the ramp | 0.3 mi | |
| Turn right onto State Highway 24 (MN 24) | 3.1 mi | |
| Continue onto Center Street (MN 24) | 0.7 mi | |
| Turn left onto US 10 | 43.7 mi | |
| Keep right onto Paul Bunyan Expressway (MN 371 W) | 27.8 mi | |
| Continue onto MN 371 | 16.9 mi | |
| Make a slight left onto Old MN 371 | 200 feet | |
| Turn left onto Old MN 371 | 500 feet | |
| Continue onto Old MN 371 | 2.7 mi | |
| Turn left onto County Highway 17 (CR 17) | 0.7 mi | |
| Turn right onto 9th Avenue Southwest (CR 114) | 0.2 mi | |
| Continue onto 52nd Street Southwest (CR 114) | 3.0 mi | |
| Continue onto 21st Avenue Southwest (CR 114) | 0.9 mi | |
| Continue onto 48th Street Southwest (CR 114) | 0.8 mi | |
| Turn left onto County Road 1 Southwest (CR 1) | 1.2 mi | |
| Turn right onto 48th Street Southwest (CR 28) | 6.7 mi | |
| Continue onto 56th Avenue Southwest (CR 25) | 0.4 mi | |
| You have arrived at your destination, on the left |
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La Crosse, WI, USA - Minnesota, USA