I 65 $south, I 64 $east
510.7 mi9 hours 16 mins
| Head east on South Street | 3.6 mi | |
| Take the ramp on the right | 0.4 mi | |
| Merge left onto I 65 S | 42.4 mi | |
| Keep left onto I 65 S | 130.0 mi | |
| Take the ramp towards I 64: Lexington | 100 feet | |
| Keep left towards I 64 East: Lexington | 0.8 mi | |
| Merge left onto I 64 E | 74.9 mi | |
| Take exit 111 on the left towards I 64 East: Winchester | 16.6 mi | |
| Keep right towards Mountain Parkway east | 42.6 mi | |
| Take the ramp | 0.3 mi | |
| Merge left onto KY 15 Spur | 18.1 mi | |
| Turn left onto Park Road (KY 15) | 29.9 mi | |
| Take the ramp onto KY 15 | 2.1 mi | |
| Turn right onto KY 15 | 29.5 mi | |
| Turn right to stay on KY 15 | 2.3 mi | |
| Continue onto US 119 | 10.3 mi | |
| Keep right at the fork | 0.4 mi | |
| Merge right onto US 23 | 18.7 mi | |
| Take the ramp towards VA 58 East Alternate: Coeburn | 0.2 mi | |
| Merge left onto Norton Coeburn Road (US 58 Alternate) | 7.5 mi | |
| Continue onto Front Street West (US 58 Alternate) | 13.0 mi | |
| Continue onto Trail of the Lonesome Pine (US 58 Alternate) | 12.0 mi | |
| Continue onto US 58 Alternate | 2.9 mi | |
| Turn right onto US 19 | 1.1 mi | |
| Continue onto US 19 | 11.6 mi | |
| Turn left onto West Main Street (US 11) | 3.6 mi | |
| Continue onto Lee Highway (US 11) | 0.4 mi | |
| Continue onto Jeb Stuart Highway (US 58) | 9.4 mi | |
| Continue onto North Beaver Dam Avenue (US 58) | 0.5 mi | |
| Continue onto West Laurel Avenue (US 58) | 0.4 mi | |
| Continue onto East 3rd Street (US 58) | 400 feet | |
| Turn right onto Douglas Drive (US 58) | 0.5 mi | |
| Continue onto Jeb Stuart Highway (US 58) | 0.5 mi | |
| Make a slight right onto Mountain City Road (SR 91) | 12.4 mi | |
| Turn left onto North Shady Street (US 421) | 11.7 mi | |
| Turn right onto Old US 421 | 0 feet | |
| You have arrived at your destination |
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Lafayette, Indiana - Zionville, North Carolina