US 65, I 40
909.2 mi14 hours 48 mins
| Head southwest on Spec Wilson (US 11) | 400 feet | |
| Turn right onto Carroll Gartin Boulevard | 0.4 mi | |
| Turn left onto Sawmill Road | 0.2 mi | |
| Keep right onto Sawmill Road | 900 feet | |
| Continue onto West 5th Street | 0.3 mi | |
| Continue onto Veterans Memorial Highway (US 84) | 27.2 mi | |
| Take the ramp | 0.2 mi | |
| Merge left onto US 49 | 57.7 mi | |
| Take the ramp on the left towards US 49 South: Hattiesburg | 400 feet | |
| Take the ramp | 0.4 mi | |
| Keep left onto US 49 N | 0.8 mi | |
| Merge left onto I 20 | 1.6 mi | |
| Keep right towards I 20 West: Vicksburg | 39.1 mi | |
| Merge right onto I 20 | 3.8 mi | |
| Keep right onto I 20 | 19.5 mi | |
| Take the ramp | 0.4 mi | |
| Turn right onto US 65 | 30.0 mi | |
| Turn left onto Lake Street (US 65) | 35.8 mi | |
| Turn left onto US 65 | 4.7 mi | |
| Continue onto US 65 | 78.0 mi | |
| Take the ramp onto US 65B | 8.6 mi | |
| Keep left onto US 65B N | 0.7 mi | |
| Merge left onto I 530 N | 35.1 mi | |
| Continue onto I 30 | 4.2 mi | |
| Keep left towards I 40 West: Conway | 0.3 mi | |
| Keep left onto US 65 N | 145.6 mi | |
| Continue onto I 40 | 51.9 mi | |
| Take exit 286 towards OK 351: Muskogee | 0.4 mi | |
| Continue onto Muskogee Turnpike (OK 351 W) | 14.4 mi | |
| Keep right onto Muskogee Turnpike (OK 351) | 41.3 mi | |
| Continue onto Disabled American Veterans Highway (OK 51) | 3.4 mi | |
| Continue onto Broken Arrow Expressway (OK 51) | 2.6 mi | |
| Take the ramp towards US 169 North: Owasso | 0.3 mi | |
| Merge left onto Representative Sue Tibbs Memorial Highway (US 169 N) | 2.9 mi | |
| Continue onto Pearl Harbor Memorial Expressway (US 169 N) | 1.3 mi | |
| Take the ramp towards I 244: Joplin | 600 feet | |
| Keep left towards I 244 West: Oklahoma City | 0.5 mi | |
| Merge left onto Martin Luther King, Junior Memorial Expressway (I 244 W) | 7.6 mi | |
| Take exit 5B on the left towards US 64 West: Sand Springs | 24.4 mi | |
| Continue onto Cimarron Turnpike (US 412 W) | 44.4 mi | |
| Keep right towards US 177: Noble | 14.4 mi | |
| Take the ramp towards I 35 North | 0.4 mi | |
| Merge left onto World War II Veterans Memorial Highway (I 35 N) | 41.4 mi | |
| Continue onto Kansas Turnpike (I 35 N) | 41.7 mi | |
| Take the ramp towards I 135: South Wichita | 0.6 mi | |
| Continue onto I 135 N | 72.7 mi | |
| Take the ramp towards Smokey Valley Road | 1,000 feet | |
| Turn left onto Smoky Valley Road (US 81 Business) | 2.5 mi | |
| Turn right onto South Cole Street (US 81 Business) | 1.3 mi | |
| Turn left onto East McPherson Street (KS 4) | 0.5 mi | |
| Turn left onto South Main Street (KS 4) | 40.6 mi | |
| Turn left onto 6th Road | 2.2 mi | |
| Turn left | 0.2 mi | |
| You have arrived at your destination |
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Laurel, Mississippi - Kansas