How to get from Lexington, Kentucky to St Louis, Missouri

Discover, print or download the driving directions for the best route to go from Lexington, Kentucky to St Louis, Missouri.

Enlarge the route map Lexington, Kentucky - St Louis, Missouri

Driving directions from Lexington, Kentucky to St Louis, Missouri

I 64 $west, I 64 $west; US 50 $west

336.5 mi5 hours 4 mins

Head northeast on South Broadway (US 27) 200 feet
Turn left onto West Main Street (US 25) 0.5 mi
Turn right onto Newtown Pike (US 25) 3.4 mi
Take the ramp 0.3 mi
Merge left onto I 64 W 2.2 mi
Keep left towards I 64 West: Frankfort 250.3 mi
Keep right towards I 57 North 4.6 mi
Take the ramp on the left towards I 64 West: Saint Louis 72.4 mi
Keep right towards IL 3 South: Cahokia 1.6 mi
Keep left towards I 64 West 0.4 mi
Take exit 40A towards Stadium 0.3 mi
Turn left onto South 9th Street 800 feet
Turn left onto Market Street 0.3 mi
You have arrived at your destination

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Lexington, Kentucky - St Louis, Missouri

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