I 49 $south; US 71 $south, MO 43
219.5 mi3 hours 25 mins
| Head north on South Water Street | 300 feet | |
| Turn right onto East Kansas Street | 300 feet | |
| Turn right onto South Missouri Street | 500 feet | |
| Turn right onto East Mill Street | 0.4 mi | |
| Continue slightly left onto West Liberty Drive | 0.7 mi | |
| Turn right onto MO 291 | 0.5 mi | |
| Turn left onto West Kansas Street | 0.6 mi | |
| Go straight onto MO 152 W | 600 feet | |
| Turn left towards I 35 South: Kansas City | 0.2 mi | |
| Merge left onto Chicago-Kansas City Expressway (I 35 S) | 1.4 mi | |
| Keep left onto Chicago-Kansas City Expressway (I 35 S) | 1.5 mi | |
| Take exit 12 towards I 435 South: Saint Louis | 0.7 mi | |
| Merge left onto I 435 | 9.6 mi | |
| Keep left onto Lamar Hunt Memorial Highway (I 435) | 8.9 mi | |
| Take exit 71 towards I 49 South: Joplin | 0.7 mi | |
| Keep left at the fork | 800 feet | |
| Keep left towards I 49 South: Joplin | 0.3 mi | |
| Merge left onto I 49 S | 24.7 mi | |
| Keep left onto I 49 S | 105.3 mi | |
| Take exit 53 towards I 49 Business: Webb City | 800 feet | |
| Turn right onto I 49 Business | 1.4 mi | |
| Keep left onto I 49 Business | 5.3 mi | |
| Keep left towards MO 249 South: Joplin | 6.2 mi | |
| Continue onto I 49 S | 15.0 mi | |
| Take the ramp | 0.3 mi | |
| Keep right at the fork | 300 feet | |
| Go straight onto US 60 | 10.8 mi | |
| Enter the roundabout and take the 3rd exit onto Cherokee (MO 43) | 300 feet | |
| Exit the roundabout onto Cherokee (MO 43) | 11.1 mi | |
| Make a slight left onto MO 43 | 11.3 mi | |
| Turn right onto MO 43 | 2.1 mi | |
| You have arrived at your destination, on the left |
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Liberty, Missouri - South West City, Missouri