US 23 $south, I 75 $south; US 23 $south
621.6 mi10 hours 25 mins
| Head west on West Traverse Bay State Road (F-41) | 0.6 mi | |
| Continue onto Old M-171 (F-41) | 1.6 mi | |
| Turn left onto State Highway 72 (M 72) | 3.0 mi | |
| Continue onto M-72 (M 72) | 3.0 mi | |
| Continue onto West Main Street (M 72) | 0.3 mi | |
| Make a sharp right onto South State Street (US 23) | 16.5 mi | |
| Continue onto North State Street (US 23) | 1.3 mi | |
| Continue onto North Huron Road (US 23) | 4.7 mi | |
| Continue onto North Huron Drive (US 23) | 1.2 mi | |
| Continue onto North Huron Road (US 23) | 6.9 mi | |
| Continue onto West Bay Street (US 23) | 1.4 mi | |
| Continue onto East Lake Street (US 23) | 2.7 mi | |
| Continue onto North Huron Road (US 23) | 26.0 mi | |
| Continue onto East Center Road (US 23) | 0.8 mi | |
| Continue onto West Huron Road (US 23) | 6.3 mi | |
| Continue onto North Main Street (US 23) | 1.0 mi | |
| Continue onto South Huron Road (US 23) | 1.7 mi | |
| Take the ramp on the right onto US 23 S | 2.2 mi | |
| Keep left towards I 75 South: Saginaw | 73.8 mi | |
| Take the ramp towards US 23: Ann Arbor | 600 feet | |
| Continue towards US 23: Ann Arbor | 45.3 mi | |
| Keep left towards US 23 South: Plymouth | 0.5 mi | |
| Continue onto US 23 S | 1.9 mi | |
| Keep right towards US 23 South: Ann Arbor | 0.6 mi | |
| Continue onto US 23 S | 52.0 mi | |
| Take exit 6 towards Dussel Drive | 0.3 mi | |
| Turn left onto Salisbury Road (CR 91) | 900 feet | |
| Continue onto West Dussel Drive (CR 91) | 1.4 mi | |
| Turn left onto Reynolds Road (US 20) | 500 feet | |
| Take the ramp on the right | 0.5 mi | |
| Continue straight | 700 feet | |
| Keep right at the fork | 0.3 mi | |
| Merge left onto Ohio Turnpike (I 80 E) | 81.8 mi | |
| Keep left onto Ohio Turnpike (I 80 E) | 9.2 mi | |
| Keep right onto I 480 E | 26.3 mi | |
| Keep right onto Outerbelt South Freeway (I 480 E) | 2.5 mi | |
| Merge left onto Outerbelt East Freeway (I 271 S) | 3.0 mi | |
| Keep right towards I 480: Youngstown | 10.6 mi | |
| Take the ramp towards Youngstown | 0.5 mi | |
| Keep right towards Youngstown | 1,000 feet | |
| Merge left onto Ohio Turnpike (I 80 E) | 53.8 mi | |
| Continue onto Pennsylvania Turnpike (I 76 E) | 1.2 mi | |
| Keep left towards E-ZPass Express | 29.6 mi | |
| Keep right onto Pennsylvania Turnpike (I 76 E) | 115.0 mi | |
| Take the ramp towards Bedford | 0.5 mi | |
| Keep right towards Bedford | 100 feet | |
| Turn right onto North Richard Street (US 220 Business) | 2.5 mi | |
| Turn left onto East Penn Street | 0.6 mi | |
| Continue onto Lincoln Highway (US 30 Business) | 6.2 mi | |
| Take the ramp towards Everett | 0.4 mi | |
| Turn right onto West 5th Avenue | 0.5 mi | |
| Turn left onto Providence Street | 400 feet | |
| Make a slight right onto West 4th Avenue | 0.4 mi | |
| Continue onto Clear Ridge Road (PA 26) | 7.0 mi | |
| Turn right to stay on Clear Ridge Road (PA 26) | 11.5 mi | |
| You have arrived at your destination |
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Lincoln, Michigan - Artemas, Pennsylvania