How to get from Louisville, Kentucky to St Louis, Missouri

Discover, print or download the driving directions for the best route to go from Louisville, Kentucky to St Louis, Missouri.

Enlarge the route map Louisville, Kentucky - St Louis, Missouri

Driving directions from Louisville, Kentucky to St Louis, Missouri

I 64 $west, I 64 $west; US 50 $west

259.7 mi3 hours 52 mins

Head east on West Jefferson Street 400 feet
Turn left onto South 9th Street 600 feet
Take the ramp 500 feet
Keep left at the fork 0.3 mi
Merge left onto I 64 W 179.3 mi
Keep right towards I 57 North 4.6 mi
Take the ramp on the left towards I 64 West: Saint Louis 72.4 mi
Keep right towards IL 3 South: Cahokia 1.6 mi
Keep left towards I 64 West 0.4 mi
Take exit 40A towards Stadium 0.3 mi
Turn left onto South 9th Street 800 feet
Turn left onto Market Street 0.3 mi
You have arrived at your destination

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Louisville, Kentucky - St Louis, Missouri

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