MS 19, US 49
224.7 mi4 hours 5 mins
| Head west on West Main Street (MS 14) | 300 feet | |
| Turn left onto South Church Avenue (MS 397) | 2.5 mi | |
| Turn left onto MS 15 | 20.2 mi | |
| Turn left onto County Road 561 | 1.3 mi | |
| Go straight onto Pecan Avenue | 1.8 mi | |
| Turn right onto West Beacon Street (MS 16) | 200 feet | |
| Turn left onto Church Avenue | 300 feet | |
| Turn left onto Main Street (MS 16) | 900 feet | |
| Turn right onto Holland Avenue (MS 19) | 36.7 mi | |
| Turn right onto Airport Boulevard (MS 19) | 1.1 mi | |
| Turn right onto North Frontage Road | 900 feet | |
| Take the ramp on the left | 0.2 mi | |
| Merge left onto I 20 | 1.6 mi | |
| Keep left towards I 59 South: Laurel | 53.3 mi | |
| Continue onto Lance Corporal Roy M Wheat Memorial Highway (I 59 S) | 35.6 mi | |
| Take the ramp towards US 98 East: Lucedale | 3.2 mi | |
| Take the ramp towards US 49: Wiggins | 0.3 mi | |
| Keep left towards Multi Purpose Center | 800 feet | |
| Turn right onto US 49 | 58.1 mi | |
| Go straight onto US 49 | 4.6 mi | |
| Turn right onto West Beach Boulevard (US 90) | 3.6 mi | |
| Turn left onto Jeff Davis Avenue | 0 feet | |
| You have arrived at your destination |
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Louisville, Mississippi - Long Beach, Mississippi