I 40, I 81 $north
671.0 mi10 hours 17 mins
| Head west on Burwood Avenue (TN 45) | 500 feet | |
| Make a U-turn and continue on Burwood Avenue (TN 45) | 1.9 mi | |
| Continue onto Old Hickory Boulevard (SR 45) | 0.5 mi | |
| Continue onto Robinson Road (SR 45) | 1.6 mi | |
| Continue onto Old Hickory Boulevard (SR 45) | 6.6 mi | |
| Take the ramp on the left | 0.3 mi | |
| Merge left onto I 40 | 199.9 mi | |
| Keep left towards I 81 North: Bristol | 391.1 mi | |
| Take the ramp towards VA 7: Winchester | 0.2 mi | |
| Keep left at the fork | 300 feet | |
| Turn left onto Berryville Pike (VA 7) | 3.5 mi | |
| Continue onto Harry Flood Byrd Memorial Highway (VA 7) | 5.2 mi | |
| Take the ramp towards US 340: Berryville | 700 feet | |
| Keep left at the fork | 100 feet | |
| Turn left onto Lord Fairfax Highway (US 340 E) | 4.1 mi | |
| Continue onto Berryville Pike (US 340) | 8.7 mi | |
| Take the ramp towards US 340 North: Charles Town | 0.3 mi | |
| Keep right onto US 340 E | 23.4 mi | |
| Take the ramp towards I 70 East: Baltimore | 0.7 mi | |
| Merge left onto I 70 N | 0.5 mi | |
| Continue onto I 70 | 19.6 mi | |
| Take the ramp towards MD 94: Woodbine | 0.4 mi | |
| Keep left at the fork | 100 feet | |
| Turn left onto Woodbine Road (MD 94) | 0.6 mi | |
| Continue straight onto Woodbine Road | 1.4 mi | |
| You have arrived at your destination |
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Madison, Tennessee - Woodbine, Maryland