Dwight D. Eisenhower Highway, I 29 $north; US 71 $north
160.4 mi2 hours 27 mins
| Head south on South 4th Street | 600 feet | |
| Turn left onto Pierre Street | 900 feet | |
| Continue onto Pillsbury Drive | 8.3 mi | |
| Continue onto KS 177 S | 0.2 mi | |
| Take the ramp towards I-70 East | 0.2 mi | |
| Merge left onto Dwight D. Eisenhower Highway (I 70) | 41.1 mi | |
| Keep left onto Dwight D. Eisenhower Highway (I 70) | 10.5 mi | |
| Keep left towards I-70 East | 2.1 mi | |
| Merge right onto Kansas Turnpike (I 70) | 19.2 mi | |
| Take the ramp towards US 40 | 0.4 mi | |
| Go straight | 400 feet | |
| Go straight onto North 3rd Street (US 40) | 0.6 mi | |
| Turn right onto US 24 E | 26.4 mi | |
| Turn left onto North 110th Street | 0.4 mi | |
| Turn right onto Parallel Parkway | 1.1 mi | |
| Take the ramp on the right towards I 435 North | 0.2 mi | |
| Merge left onto I 435 | 16.8 mi | |
| Take exit 31 on the left towards I 29 North: Saint Joseph | 0.8 mi | |
| Merge left onto I 29 N | 25.2 mi | |
| Take exit 43 towards I 229 North: Downtown Saint Joseph | 0.5 mi | |
| Continue onto I 229 N | 5.7 mi | |
| Take the ramp | 0.3 mi | |
| Continue onto Edmond Street | 400 feet | |
| Turn left onto South 4th Street | 300 feet | |
| Turn left onto Felix Street | 200 feet | |
| You have arrived at your destination |
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Manhattan, Kansas - St Joseph, Missouri