How to get from Maryville, Missouri to Cape Girardeau, Missouri

Discover, print or download the driving directions for the best route to go from Maryville, Missouri to Cape Girardeau, Missouri.

Enlarge the route map Maryville, Missouri - Cape Girardeau, Missouri

Driving directions from Maryville, Missouri to Cape Girardeau, Missouri

I 70 $east; US 40 $east, I 55 $south

442.5 mi6 hours 43 mins

Head south on North Main Street (US 71 Business) 2.4 mi
Turn right onto US 71 30.0 mi
Take the ramp on the left towards I 29 South: Kansas City 3.2 mi
Continue onto I 29 S 37.2 mi
Merge right onto I 29 S 2.3 mi
Keep left towards I 29 South: Kansas City 14.6 mi
Merge left onto I 29 S 4.4 mi
Keep left towards I 70 East: Saint Louis 30.2 mi
Continue onto I 70 E 69.3 mi
Keep left onto I 70 E 108.5 mi
Take exit 210A towards I 64 East: Chesterfield 25.3 mi
Take exit 25 towards I 270: Chicago 0.3 mi
Keep right towards I 270 South: Memphis 0.3 mi
Merge left onto I 270 S 11.5 mi
Take exit 1A towards I 55: Saint Louis 0.4 mi
Keep right towards I 55 South: Memphis 0.4 mi
Merge left onto I 55 S 100.0 mi
Take exit 96 towards MO K: Cape Girardeau 0.2 mi
Turn left onto William Street (MO K) 2.1 mi
You have arrived at your destination

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Maryville, Missouri - Cape Girardeau, Missouri

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