I 40, I 81 $north
147.9 mi2 hours 32 mins
| Head northeast on West Broadway Avenue (US 411) | 0.2 mi | |
| Turn left onto North Cusick Street | 0.2 mi | |
| Continue onto South Calderwood Street | 0.9 mi | |
| Continue onto Louisville Road | 0.3 mi | |
| Turn right onto US 129 | 1.5 mi | |
| Keep left onto Alcoa Highway (US 129) | 12.4 mi | |
| Keep right towards I 40 East: Asheville | 500 feet | |
| Keep left towards I 40 East: Asheville | 0.4 mi | |
| Merge left onto I 40 | 34.1 mi | |
| Keep left towards I 81 North: Bristol | 56.6 mi | |
| Take exit 57A towards I 26 East: Johnson City | 0.4 mi | |
| Merge left onto I 26 E | 11.4 mi | |
| Continue onto I 26 E | 3.7 mi | |
| Take the ramp towards US 321: Elizabethton | 700 feet | |
| Keep right at the fork | 400 feet | |
| Merge left onto University Parkway (US 321) | 500 feet | |
| Continue onto US 321 N | 3.8 mi | |
| Continue onto West Elk Avenue (US 321) | 3.6 mi | |
| Keep right onto W Elk Ave | 0.3 mi | |
| Continue onto East Elk Avenue | 0.3 mi | |
| Turn right onto South Sycamore Street | 0.7 mi | |
| Turn right onto Veterans Memorial Parkway (US 19E) | 2.3 mi | |
| Continue onto Rod Swift Bridge (US 19E) | 12.4 mi | |
| Go straight onto US 19E | 1.9 mi | |
| You have arrived at your destination |
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Maryville, Tennessee - Roan Mountain, Tennessee