US 63, I 44 $east
272.3 mi5 hours 13 mins
| Head west on Main Street (AR 69) | 400 feet | |
| Make a slight right onto Dixon Street (AR 9) | 4.0 mi | |
| Continue onto Hwy 9 | 16.3 mi | |
| Turn left onto Hwy 9 | 5.7 mi | |
| Turn left onto Moko Road (AR 395) | 0.3 mi | |
| Continue onto Hwy 395 | 6.5 mi | |
| Turn right onto Hwy 395 | 21.6 mi | |
| Turn left onto Jan Howard Expressway (US 63) | 3.3 mi | |
| Continue onto Jan Howard Expw (US 63) | 1.0 mi | |
| Continue onto Porter Wagoner Boulevard (US 63) | 0.7 mi | |
| Continue onto Sunset Terrace (US 63) | 28.5 mi | |
| Keep right towards US 63 North: Houston | 0.3 mi | |
| Continue onto US 63 | 65.8 mi | |
| Turn left onto University Drive (MO E) | 0.2 mi | |
| Take the ramp on the right towards I 44 East: Saint Louis | 600 feet | |
| Merge left onto I 44 E | 54.3 mi | |
| Take the ramp towards MO 47: Saint Clair | 0.3 mi | |
| Turn left onto North Main Street (MO 47) | 700 feet | |
| Continue onto S Highway 47 (MO 47) | 5.6 mi | |
| Turn left onto US 50 W | 0.5 mi | |
| Turn right onto N Highway 47 (MO 47) | 0.3 mi | |
| Continue onto Route 47 (MO 47) | 0.9 mi | |
| Continue onto Highway 47 (MO 47) | 9.9 mi | |
| Turn right onto MO 94 | 0.7 mi | |
| Continue onto State Highway TT (MO TT) | 3.5 mi | |
| Turn left onto MO T | 12.5 mi | |
| Turn right onto Veterans Memorial Parkway | 300 feet | |
| Turn left onto Highway W (MO W) | 700 feet | |
| Take the ramp on the left | 0.2 mi | |
| Merge left onto I 70 W | 3.4 mi | |
| Take the ramp | 0.2 mi | |
| Turn right onto Elm Street (MO F) | 100 feet | |
| Turn right | 0.2 mi | |
| Turn left onto State Highway J (MO J) | 11.5 mi | |
| Turn right to stay on State Highway J (MO J) | 800 feet | |
| Continue onto State Highway H (MO H) | 11.0 mi | |
| Make a slight left to stay on State Highway H (MO H) | 200 feet | |
| Turn right onto State Highway E (MO E) | 2.5 mi | |
| You have arrived at your destination |
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Melbourne, Arkansas - Silex, Missouri