How to get from Memphis, Tennessee to Louisville, Kentucky

Discover, print or download the driving directions for the best route to go from Memphis, Tennessee to Louisville, Kentucky.

Enlarge the route map Memphis, Tennessee - Louisville, Kentucky

Driving directions from Memphis, Tennessee to Louisville, Kentucky

I 40, I 65 $north

381.2 mi5 hours 56 mins

Head east on Poplar Avenue 0.3 mi
Turn left onto North Danny Thomas Boulevard (US 51) 0.6 mi
Turn right onto North Parkway 3.1 mi
Turn right onto East Parkway North (US 64) 0.2 mi
Turn left onto Sam Cooper Boulevard 6.0 mi
Continue onto I 40 194.5 mi
Keep left onto I 40 1.9 mi
Take the ramp on the left towards I 65 North: Louisville 0.4 mi
Merge right onto I 65 N 1.7 mi
Keep left towards I 24 West: Clarksville 2.1 mi
Keep right towards I 65 North: Louisville 7.1 mi
Keep left onto I 65 N 161.5 mi
Take the ramp towards US 150 0.2 mi
Go straight onto South Brook Street 200 feet
Turn left onto East Broadway (US 150) 0.8 mi
Turn right onto South 9th Street 0.5 mi
Turn left onto West Jefferson Street 500 feet
You have arrived at your destination

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Memphis, Tennessee - Louisville, Kentucky

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