How to get from Mesa, Arizona to Sioux Falls, South Dakota

Discover, print or download the driving directions for the best route to go from Mesa, Arizona to Sioux Falls, South Dakota.

Enlarge the route map Mesa, Arizona - Sioux Falls, South Dakota

Driving directions from Mesa, Arizona to Sioux Falls, South Dakota

I 25 $north, I 80

1,498.0 mi22 hours 42 mins

Head north on North Center Street 0.4 mi
Turn left onto West University Drive 0.5 mi
Turn right onto North Country Club Drive (AZ 87) 2.8 mi
Continue onto North Beeline Highway (AZ 87) 57.0 mi
Continue onto SR 87 1.7 mi
Continue onto AZ 87 3.3 mi
Continue onto SR 87 0.3 mi
Continue onto AZ 87 10.6 mi
Take the ramp 300 feet
Continue straight 400 feet
Merge left onto AZ 260 52.9 mi
Turn left onto West 3rd Street North (AZ 277) 6.8 mi
Turn left onto AZ 377 33.9 mi
Turn left onto Show Low-Holbrook Highway (AZ 77) 1.6 mi
Continue onto Holbrook-Springerville Highway (US 180) 0.5 mi
Continue onto Navajo Boulevard (US 180) 0.2 mi
Continue onto I 40 BUS 0.7 mi
Take the ramp on the right onto AZ 77 0.6 mi
Merge left onto Purple Heart Trail (I 40) 230.6 mi
Take the ramp towards I 25 North: Santa Fe 0.3 mi
Keep left towards I 25 North: Santa Fe 0.8 mi
Merge left onto Pan American Freeway (I 25 N) 333.3 mi
Take the ramp towards 13th Street 0.4 mi
Merge left onto I 25 N 0.6 mi
Continue onto I 25 N 93.8 mi
Take exit 194 700 feet
Keep right towards E 470 TOLL: Limon 0.5 mi
Merge left onto E-470 34.5 mi
Take exit 35 towards I 76 East: Fort Morgan 1.1 mi
Merge left onto I 76 E 165.1 mi
Continue onto I 76 N 2.6 mi
Keep left at the fork 0.7 mi
Merge right onto I 80 209.7 mi
Take the ramp towards Grand Island 0.5 mi
Turn left 0.8 mi
Continue onto South Locust Street 3.6 mi
Turn right onto Highway 34 (US 34) 2.4 mi
Turn left onto Husker Highway 0.7 mi
Continue onto South Gunbarrel Road 4.1 mi
Turn right onto Highway 30 (US 30) 17.8 mi
Continue onto G Street (US 30) 0.9 mi
Continue slightly right onto 16th Street (US 30) 0.6 mi
Continue onto Highway 30 (US 30) 25.9 mi
Turn left onto 370th Avenue 8.9 mi
Continue onto Gleason Street 0.2 mi
Turn right onto Columbus Avenue (NE 22) 0.5 mi
Continue onto State Highway 22 (NE 22) 5.7 mi
Turn left onto 280th Avenue 1.5 mi
Turn right onto 265th Street 1.1 mi
Turn left onto US Highway 81 (US 81 N) 16.8 mi
Continue onto Highway 81 (US 81 N) 17.5 mi
Continue onto South 13th Street (US 81 N) 3.3 mi
Continue onto North 13th Street (US 81) 4.0 mi
Continue onto Highway 81 (US 81) 19.0 mi
Turn right onto Highway 20 (US 20) 11.6 mi
Continue onto 1st Street (US 20) 0.4 mi
Continue onto Highway 20 (US 20) 5.6 mi
Continue onto Willow Street (US 20) 0.3 mi
Continue onto Highway 20 (US 20) 2.1 mi
Turn left onto Highway 15 (NE 15) 15.5 mi
Turn right onto 887 Road 3.2 mi
Turn right onto Highway 12 (NE 12) 0.3 mi
Continue onto 1st Street (NE 12) 0.2 mi
Continue onto Highway 12 (NE 12) 3.9 mi
Turn left onto Highway 15 (NE 15) 2.8 mi
Continue onto Vermillion-Newcastle Bridge (NE 15) 2.5 mi
Turn right onto 320th Street 0.4 mi
Continue onto South Dakota Street 2.8 mi
Turn right onto East Main Street 0.5 mi
Turn left onto North Plum Street 0.5 mi
Turn right onto East Cherry Street (SD 50 Bus) 1.4 mi
Continue onto South Dakota Highway 50 (SD 50 E) 5.3 mi
Take the ramp on the left towards I 29 North: Beresford 0.3 mi
Merge left onto I 29 N 48.3 mi
Take the ramp onto I 229 3.4 mi
Take the ramp onto I 229 Business 0.2 mi
Turn left onto South Minnesota Avenue (I 229 Business N) 2.5 mi
You have arrived at your destination

Print directions
Mesa, Arizona - Sioux Falls, South Dakota

At How to get from we offer the best route to any destination. We use the most advanced technologies of maps representation, route calculation, traffic information updated in real time and distance calculator to give you a detailed itinerary to get to your destination.