SR 63, I 40
225.6 mi3 hours 59 mins
| Head east on West Cumberland Avenue (KY 74) | 0.6 mi | |
| Turn right onto US 25E | 3.2 mi | |
| Keep right onto Cumberland Gap Parkway (US 25E) | 0.4 mi | |
| Keep left onto Cumberland Gap Parkway (US 25E) | 700 feet | |
| Keep right onto Cumberland Gap Parkway (US 25E) | 500 feet | |
| Keep right onto Cumberland Gap Highway (US 25E) | 0.5 mi | |
| Keep right at the fork | 500 feet | |
| Merge left onto SR 63 | 34.3 mi | |
| Continue onto West Central Avenue (US 25W) | 3.8 mi | |
| Continue onto Royal Blue Road (US 25W) | 600 feet | |
| Take the ramp towards Knoxville | 5.7 mi | |
| Take the ramp towards US 25W South: Rocky Top | 0.2 mi | |
| Keep right onto I 75 | 200 feet | |
| Make a slight right onto North Main Street (US 25W) | 0.8 mi | |
| Turn right onto Creek Street (SR 116) | 3.8 mi | |
| Turn left onto Briceville Highway (SR 116) | 200 feet | |
| Turn right to stay on Briceville Highway (SR 116) | 5.2 mi | |
| Turn left to stay on Briceville Highway (SR 330) | 200 feet | |
| Continue onto Frost Bottom Road (SR 330) | 7.1 mi | |
| Turn right onto Dutch Valley Road (SR 330) | 0.4 mi | |
| Continue onto Walden Avenue (SR 330) | 0.5 mi | |
| Make a slight left onto East Spring Street (SR 330) | 0.6 mi | |
| Turn right onto Main Street (SR 330) | 700 feet | |
| Continue onto Railroad Avenue (SR 330) | 0.2 mi | |
| Turn right onto Winter Gap Road (SR 330) | 400 feet | |
| Turn left onto East Tri County Boulevard (SR 61) | 1.2 mi | |
| Continue onto Harriman Highway (SR 61) | 9.6 mi | |
| Merge right onto Bitter Creek Highway (US 27) | 800 feet | |
| Continue onto Harriman Highway (US 27) | 0.2 mi | |
| Continue onto Hannah Highway (US 27) | 2.1 mi | |
| Continue onto North Roane Street (US 27) | 4.1 mi | |
| Turn left | 1,000 feet | |
| Merge left onto I 40 | 112.2 mi | |
| Take the ramp towards I 840 West: Murfreesboro | 1.1 mi | |
| Continue onto I 840 W | 21.1 mi | |
| Take the ramp towards Us 41: Smyrna | 0.2 mi | |
| Keep left at the fork | 0.4 mi | |
| Keep right at the fork | 0.4 mi | |
| Go straight onto New Nashville Highway (US 41) | 0.8 mi | |
| Continue onto Northwest Broad Street (US 41) | 3.8 mi | |
| You have arrived at your destination |
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Middlesboro, Kentucky - Murfreesboro, Tennessee