I 24 $east, I 65 $south
680.9 mi10 hours 31 mins
| Head east on Walnut Street (IL 149) | 0.5 mi | |
| Continue onto West Main Street (IL 13) | 6.5 mi | |
| Continue onto West Walnut Street (IL 13) | 1.9 mi | |
| Keep left onto East Main Street (IL 13) | 9.7 mi | |
| Continue onto West Deyoung Street (IL 13) | 3.3 mi | |
| Take the ramp | 0.4 mi | |
| Merge left onto I 57 S | 8.5 mi | |
| Take the ramp towards I 24 East: Nashville | 1.4 mi | |
| Continue onto I 24 E | 175.1 mi | |
| Keep right towards I 24 East: Nashville | 2.3 mi | |
| Keep left towards I 24 East: Chattanooga | 2.8 mi | |
| Keep right towards I 40 West: Memphis | 0.4 mi | |
| Merge left onto I 40 | 0.6 mi | |
| Keep left towards I 65 South: Huntsville | 0.4 mi | |
| Merge right onto I 65 S | 28.8 mi | |
| Keep left onto I-65 (I 65 S) | 66.1 mi | |
| Continue onto I 65 (I 65 S) | 0.2 mi | |
| Continue onto I-65 (I 65 S) | 315.9 mi | |
| Take exit 37 towards SR 287: Gulf Shores | 0.3 mi | |
| Turn left onto Rabun Road (SR 287) | 4.4 mi | |
| Continue onto Bay Minette Bypass (AL 59) | 5.5 mi | |
| Continue onto Gulf Shores Parkway (US 31) | 17.9 mi | |
| Continue onto US 90 | 11.0 mi | |
| Turn left onto Foley Beach Express | 14.0 mi | |
| Turn left onto Canal Road (AL 180) | 2.9 mi | |
| You have arrived at your destination |
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Murphysboro, Illinois - Orange Beach, Alabama