TX 21, State Highway 21
320.3 mi5 hours 5 mins
| Head northwest on East Main Street (TX 7) | 100 feet | |
| Turn left onto South Street (US 59 BUS) | 4.5 mi | |
| Continue onto US 59 S | 11.9 mi | |
| Turn right onto Spence Street (FM 3439) | 0.7 mi | |
| Turn right onto Ellen Trout Drive (US 69 N) | 1.7 mi | |
| Take the ramp towards Loop 287 South | 0.8 mi | |
| Turn left onto John Redditt Drive (TX 103) | 0.7 mi | |
| Take the ramp onto TX 103 | 11.7 mi | |
| Continue onto TX 7 | 31.3 mi | |
| Turn right onto 5th Street (US 287) | 200 feet | |
| Turn left onto East Houston Avenue (US 287) | 300 feet | |
| Turn left onto South 4th Street (US 287) | 200 feet | |
| Turn right onto East Goliad Avenue (TX 7) | 1.6 mi | |
| Turn left onto TX 21 | 66.1 mi | |
| Merge left onto US 190 E | 0.6 mi | |
| Continue onto US 190 W | 2.3 mi | |
| Continue onto US 190 | 20.2 mi | |
| Continue onto TX 21 | 56.0 mi | |
| Turn left onto TX 21 | 0.3 mi | |
| Turn right onto State Highway 71 Frontage Road | 300 feet | |
| Take the ramp | 0.4 mi | |
| Merge left onto TX 21 W | 2.2 mi | |
| Continue onto TX 71 W | 0.7 mi | |
| Continue onto TX 21 W | 1.2 mi | |
| Continue onto TX 21 | 1.6 mi | |
| Take the ramp towards TX 21 West: San Marcos | 0.3 mi | |
| Turn left onto TX 21 | 34.7 mi | |
| Turn right | 0.3 mi | |
| Go straight onto TX 80 | 0.6 mi | |
| Make a slight left | 0.2 mi | |
| Make a slight left onto Interstate 35 Frontage Road | 0.3 mi | |
| Take the ramp on the left towards I 35 South | 0.2 mi | |
| Merge left onto I 35 S | 32.6 mi | |
| Take the ramp towards Loop 1604 South: Anderson Loop | 0.7 mi | |
| Keep left towards Loop 1604 West | 600 feet | |
| Merge left onto Anderson Loop (Loop 1604 W) | 16.8 mi | |
| Take the ramp towards I 10 East: San Antonio | 600 feet | |
| Keep right towards I 10 West: El Paso | 0.4 mi | |
| Merge left onto Interstate 10 West (I 10) | 13.9 mi | |
| Take the ramp towards US 87 BUS North: Boerne | 2.0 mi | |
| Turn right onto River Road (TX 46) | 100 feet | |
| You have arrived at your destination |
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Nacogdoches, Texas - Boerne, Texas