I 57 $south, I 65 $south
1,285.3 mi20 hours 43 mins
| Head south on Hewett Street (WI 73) | 700 feet | |
| Turn right onto West Division Street (US 10) | 500 feet | |
| Turn left onto State Highway 73 (WI 73) | 3.0 mi | |
| Go straight onto State Highway 95 (WI 95) | 8.6 mi | |
| Turn left onto County Road J (CTH J) | 3.4 mi | |
| Turn left onto County Highway K (CTH K) | 0.5 mi | |
| Turn right onto County Highway E (CTH E) | 7.8 mi | |
| Turn left onto South Hammond Street (US 12) | 2.3 mi | |
| Take the ramp on the right | 0.5 mi | |
| Merge left onto I 94 E | 129.6 mi | |
| Continue towards I 39:I 90: Chicago | 61.2 mi | |
| Take the ramp towards I 39: Bloomington | 0.8 mi | |
| Continue onto I 39 S | 2.2 mi | |
| Take the ramp towards I 39: Bloomington | 119.5 mi | |
| Keep right towards I 55 South: Peoria | 7.6 mi | |
| Keep left towards I 74 East: Indianapolis | 45.5 mi | |
| Take exit 179A towards I 57 South: Memphis | 0.5 mi | |
| Merge left onto I 57 S | 79.4 mi | |
| Keep left towards I 57 South: Memphis | 113.0 mi | |
| Take the ramp towards I 24 East: Nashville | 1.4 mi | |
| Continue onto I 24 E | 175.1 mi | |
| Keep right towards I 24 East: Nashville | 2.3 mi | |
| Keep left towards I 24 East: Chattanooga | 2.8 mi | |
| Keep right towards I 40 West: Memphis | 0.4 mi | |
| Merge left onto I 40 | 0.6 mi | |
| Keep left towards I 65 South: Huntsville | 0.4 mi | |
| Merge right onto I 65 S | 28.8 mi | |
| Keep left onto I-65 (I 65 S) | 66.1 mi | |
| Continue onto I 65 (I 65 S) | 0.2 mi | |
| Continue onto I-65 (I 65 S) | 185.5 mi | |
| Take exit 168 towards 80 | 700 feet | |
| Keep left onto US 82 | 300 feet | |
| Turn left onto West Boulevard (US 80) | 5.5 mi | |
| Turn right onto Troy Highway (US 231) | 90.7 mi | |
| Continue onto Montgomery Highway (US 231) | 3.6 mi | |
| Turn right onto Ross Clark Circle (US 84) | 4.9 mi | |
| Turn right onto South Oates Street (US 231) | 25.1 mi | |
| Take the ramp on the left | 200 feet | |
| Turn left onto FL 73 | 8.7 mi | |
| Turn right onto Jefferson Street (FL 73) | 0.9 mi | |
| Continue onto Clarksville Highway (FL 73) | 24.6 mi | |
| Turn right onto FL 20 | 0.2 mi | |
| Turn left onto FL 73 | 15.6 mi | |
| Turn right onto FL 71 | 33.0 mi | |
| Turn left onto Monument Avenue (US 98) | 0.3 mi | |
| Continue onto Constitution Drive (US 98) | 22.5 mi | |
| You have arrived at your destination |
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Neillsville, Wisconsin - Apalachicola, Florida