I 81 $south, I 59 $south
1,005.1 mi15 hours 36 mins
| Head northwest on Delaware Street | 0.3 mi | |
| Turn left to stay on Delaware Street (DE 9) | 0.6 mi | |
| Continue onto Frenchtown Road (DE 273) | 1.3 mi | |
| Continue onto Christiana Road (DE 273) | 2.8 mi | |
| Continue onto Christiana Bypass (DE 273) | 1.0 mi | |
| Continue onto Christiana Road (DE 273) | 0.6 mi | |
| Take the ramp towards I 95 Toll South: Newark | 0.6 mi | |
| Merge left onto Delaware Turnpike (I 95 S) | 6.3 mi | |
| Continue onto John F. Kennedy Memorial Highway (I 95 S) | 41.3 mi | |
| Keep right onto John F. Kennedy Memorial Highway (I 95 S) | 0.6 mi | |
| Take the ramp towards MD 43: White Marsh | 900 feet | |
| Keep right towards MD 43 West: White Marsh | 0.5 mi | |
| Merge left onto White Marsh Boulevard (MD 43) | 3.8 mi | |
| Merge left onto Baltimore Beltway (I 695 W) | 18.2 mi | |
| Take the ramp towards I 70 East: Local Traffic | 800 feet | |
| Keep right towards I 70 West: Frederick | 0.5 mi | |
| Merge left onto I 70 | 38.6 mi | |
| Take the ramp towards US 340: Charles Town | 0.3 mi | |
| Keep left towards US 15 South: Charles Town | 0.3 mi | |
| Merge left onto Jefferson National Pike (US 15 S) | 13.8 mi | |
| Continue onto Jefferson Pike (US 340 W) | 2.8 mi | |
| Continue onto Chestnut Hill Road (US 340) | 7.1 mi | |
| Take the ramp onto US 340 W | 13.3 mi | |
| Take the ramp | 0.2 mi | |
| Merge left onto Harry Flood Byrd Memorial Highway (VA 7) | 8.8 mi | |
| Take the ramp | 0.3 mi | |
| Merge left onto I 81 S | 391.2 mi | |
| Merge left onto I 40 | 52.7 mi | |
| Keep left towards I 75 South: Chattanooga | 10.2 mi | |
| Keep right onto I 75 S | 800 feet | |
| Keep left onto I 75 S | 72.9 mi | |
| Take the ramp towards I 24 West: Chattanooga | 0.6 mi | |
| Continue towards Chattanooga | 16.7 mi | |
| Take exit 167 on the left towards I 59 South: Birmingham | 0.8 mi | |
| Continue onto I 59 S | 133.6 mi | |
| Take the ramp towards 31st Street North | 900 feet | |
| Turn right onto 31st Street North | 400 feet | |
| Turn left onto 12th Avenue North | 0.5 mi | |
| Turn right onto Carraway Boulevard (US 31) | 1.2 mi | |
| Turn left onto Finley Boulevard (SR 378) | 0.6 mi | |
| Turn right onto 19th Street North | 0 feet | |
| Take the ramp | 800 feet | |
| Merge left onto I 65 N | 1.7 mi | |
| Take the ramp towards I 22 West: Memphis | 1.2 mi | |
| Continue onto I 22 W | 136.0 mi | |
| Take the ramp towards MS 9 South: Sherman | 0.3 mi | |
| Keep left at the fork | 200 feet | |
| Merge right onto MS 9 | 16.3 mi | |
| Continue onto MS 15 | 2.4 mi | |
| Turn right onto Algoma Road (MS 772) | 1.0 mi | |
| You have arrived at your destination |
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New Castle, Delaware - Algoma, Mississippi