US 22 $west; US 322 $west, I 80
231.5 mi4 hours 12 mins
| Head northwest on Bridge Street | 0.8 mi | |
| Continue onto South 3rd Street | 0.7 mi | |
| Make a slight right | 200 feet | |
| Go straight onto Market Street | 0.3 mi | |
| Turn right onto Market Street Bridge | 1.4 mi | |
| Turn left onto North Cameron Street (PA 230) | 81.4 mi | |
| Continue onto Mount Nittany Expressway (US 322) | 6.6 mi | |
| Continue onto I 99 S | 11.0 mi | |
| Keep right towards US 322 West: Philipsburg | 1.5 mi | |
| Continue onto Port Matilda Road (US 322) | 2.0 mi | |
| Continue onto Port Matilda Highway (US 322) | 1.3 mi | |
| Continue onto Twenty-Eighth Division Highway (US 322) | 6.3 mi | |
| Continue onto Railroad Street (US 322) | 1.0 mi | |
| Turn right onto North Centre Street (US 322) | 800 feet | |
| Continue onto North Front Street (US 322) | 0.3 mi | |
| Continue onto Philipsburg Bigler Highway (US 322) | 7.1 mi | |
| Continue onto Woodland Bigler Highway (US 322) | 2.8 mi | |
| Turn right onto Shawville Highway (PA 970) | 1.6 mi | |
| Take the ramp on the left | 0.3 mi | |
| Merge left onto I 80 | 61.8 mi | |
| Take the ramp towards PA 66 North: Shippenville | 3.9 mi | |
| Turn left onto US 322 | 17.3 mi | |
| Turn right onto PA 257 | 5.1 mi | |
| Continue onto East 2nd Street (US 62) | 0.2 mi | |
| Continue onto East Front Street (US 62) | 0.7 mi | |
| Continue onto West Front Street (US 62) | 400 feet | |
| Turn right onto Specialist Jonathan R. Kephart Memorial Bridge (US 62) | 0.2 mi | |
| Turn right onto Main Street (PA 8 N) | 0.2 mi | |
| Continue onto William Flinn Highway (PA 8 N) | 0.7 mi | |
| Continue onto Seneca Street (PA 8 N) | 0.5 mi | |
| Continue onto William Flinn Highway (PA 8 N) | 1.5 mi | |
| Continue onto Main Street (PA 8 N) | 1.1 mi | |
| Continue onto William Flinn Highway (PA 8 N) | 10.6 mi | |
| Continue onto Smock Boulevard (PA 8 N) | 0.3 mi | |
| Continue onto South Franklin Street (PA 8 N) | 0.3 mi | |
| Turn right onto Diamond Street (PA 27 E) | 800 feet | |
| Go straight onto East Central Avenue (PA 27) | 300 feet | |
| Turn left onto North Drake Street | 0 feet | |
| You have arrived at your destination |
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New Cumberland, Pennsylvania - Titusville, Pennsylvania