Queen Elizabeth Way, Highway 10
193.8 mi3 hours 55 mins
| Head northwest on Picton Street | 0 feet | |
| Continue onto Queen Street | 0.5 mi | |
| Turn left onto Mississagua Street | 0.8 mi | |
| Continue onto Niagara Stone Road (55) | 3.6 mi | |
| Enter the roundabout and take the 1st exit onto Niagara Stone Road (55) | 100 feet | |
| Exit the roundabout onto Niagara Stone Road (55) | 2.4 mi | |
| Turn left onto Airport Road (90) | 1.8 mi | |
| Turn left onto York Road (81) | 0.3 mi | |
| Turn right onto Glendale Avenue (89) | 400 feet | |
| Take the ramp on the right towards QEW: Toronto | 0.4 mi | |
| Merge left onto Queen Elizabeth Way (QEW N) | 37.3 mi | |
| Take exit 100 towards 407 ETR East: Hamilton | 0.8 mi | |
| Keep left towards 407 ETR East | 0.5 mi | |
| Continue onto Highway 407 ETR (407 ETR E) | 13.6 mi | |
| Take the ramp towards 403: Toronto | 0.2 mi | |
| Keep left towards 403: Toronto | 1.0 mi | |
| Merge right onto Highway 403 (403 E) | 8.0 mi | |
| Keep right towards 410: Highway 410 Brampton | 0.7 mi | |
| Keep left onto Highway 403 Collectors (403) | 0.5 mi | |
| Keep left towards 410: Brampton | 0.5 mi | |
| Keep right towards Courtneypark Drive | 0.4 mi | |
| Continue towards 410: Brampton | 12.4 mi | |
| Continue onto Highway 10 (10 N) | 3.0 mi | |
| Continue onto Hurontario Street (10) | 14.0 mi | |
| Continue onto Highway 10 (10 N) | 13.0 mi | |
| Turn left onto Highway 10 & 89 (10 N) | 2.8 mi | |
| Continue onto Main Street East (10) | 0.6 mi | |
| Turn right onto Owen Sound Street (10) | 0.8 mi | |
| Continue onto Highway 10 (10) | 21.0 mi | |
| Continue onto Toronto Road (10) | 0.2 mi | |
| Continue onto Sydenham Street (10) | 0.4 mi | |
| Continue onto Highway 10 (10) | 5.3 mi | |
| Continue onto Toronto Street South (10) | 0.9 mi | |
| Continue onto Highway 10 (10) | 14.8 mi | |
| Continue onto Toronto Sydenham Street (10) | 0.6 mi | |
| Go straight onto Highway 6/10 (6) | 4.7 mi | |
| Turn left onto Grey Road 18 (CR 18) | 3.2 mi | |
| Turn right to stay on Grey Road 18 (CR 18) | 3.0 mi | |
| Turn left onto Highway 21 (21) | 18.0 mi | |
| Continue onto North Rankin Street (21) | 1.4 mi | |
| Continue onto Albert Street N (21) | 0.5 mi | |
| Turn left onto High Street | 400 feet | |
| You have arrived at your destination, on the right |
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Niagara-on-the-Lake, Ontario - Southampton, Saugeen Shores, Ontario