US 60, Interstate 57
71.0 mi1 hour 22 mins
| Head northwest on South 3rd Street (US 60 Business) | 0.4 mi | |
| Go straight onto Park Avenue (US 45 Business) | 3.0 mi | |
| Continue onto Old Hinkleville Road (US 60) | 2.0 mi | |
| Merge left onto Old Hinkleville Road (US 60) | 10.5 mi | |
| Continue onto Paducah Rd (US 60) | 6.1 mi | |
| Continue onto West Kentucky Avenue (US 60) | 0.5 mi | |
| Continue onto Paducah Road (US 60) | 3.2 mi | |
| Continue onto Broadway (US 60) | 0.6 mi | |
| Turn left onto South 4th Street (US 60) | 0.2 mi | |
| Continue onto Main Street (US 60) | 5.9 mi | |
| Go straight onto Lee Street (US 60) | 700 feet | |
| Continue onto 4th Street (US 60) | 0.2 mi | |
| Turn right onto Green Street (US 51) | 4.8 mi | |
| Turn right to stay on US 51 | 5.2 mi | |
| Take the ramp on the right | 0.4 mi | |
| Merge left onto I 57 S | 26.2 mi | |
| Take the ramp onto US 60 Business | 0.2 mi | |
| Turn right onto US 61 | 0.5 mi | |
| Turn left onto South Kings Highway | 1.0 mi | |
| Turn left onto East Malone Avenue (US 60 Business) | 200 feet | |
| You have arrived at your destination |
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Paducah, Kentucky - Sikeston, Missouri