I 77 $north, I 81 $north
650.6 mi10 hours 29 mins
| Head southeast on North Mechanic Street (SC 28 Business) | 600 feet | |
| Turn left onto East Queen Street (SC 88) | 0.3 mi | |
| Turn left onto Greenville Street (SC 88) | 0.9 mi | |
| Continue onto Old Greenville Highway (SC 88) | 2.7 mi | |
| Continue onto State Highway 88 (SC 88) | 1.2 mi | |
| Continue onto Old Greenville Highway (SC 88) | 9.8 mi | |
| Turn right onto SC 8 | 3.4 mi | |
| Take the ramp on the left | 0.3 mi | |
| Merge left onto I 85 N | 36.5 mi | |
| Keep left onto I 85 N | 67.8 mi | |
| Take the ramp towards I 485: Pineville | 0.5 mi | |
| Keep left towards I 485 Outer North: Huntersville | 1.0 mi | |
| Merge left onto I 485 | 10.6 mi | |
| Take the ramp towards I 77: Charlotte | 0.4 mi | |
| Keep left towards I 77 North: Statesville | 1.0 mi | |
| Merge left onto I 77 N | 63.4 mi | |
| Keep right onto I 77 N | 54.1 mi | |
| Take the ramp towards I 81 North: Roanoke | 0.5 mi | |
| Merge left towards I 81 North: Roanoke | 12.0 mi | |
| Continue onto I 81 N | 102.5 mi | |
| Continue onto I 64 E | 113.3 mi | |
| Take the ramp towards VA 37 North: Romney | 0.3 mi | |
| Turn left onto VA 37 | 6.9 mi | |
| Take the ramp towards US 522: Winchester | 0.3 mi | |
| Make a sharp left onto North Frederick Pike (US 522) | 19.6 mi | |
| Continue onto Valley Road (US 522) | 12.5 mi | |
| Continue onto South Washington Street (US 522) | 2.0 mi | |
| Continue onto Hancock Road (US 522) | 4.5 mi | |
| Continue onto Warfordsburg Road (US 522) | 1.2 mi | |
| Merge right onto Dwight D Eisenhower Highway (I 70) | 0.9 mi | |
| Continue onto I 70 W | 23.2 mi | |
| Merge left onto Lincoln Highway (US 30) | 1,000 feet | |
| Turn right onto I 70 W | 1.6 mi | |
| Keep right towards I 70 West: Pittsburgh | 0.4 mi | |
| Merge left onto Pennsylvania Turnpike (I 70 W) | 15.5 mi | |
| Take the ramp towards Altoona | 0.3 mi | |
| Keep left towards Altoona | 100 feet | |
| Turn left onto North Richard Street (US 220 Business) | 0.3 mi | |
| Take the ramp on the left towards I 99: Cumberland | 0.2 mi | |
| Keep right towards I 99 North: Altoona | 0.3 mi | |
| Merge left onto I 99 N | 68.6 mi | |
| Take the ramp towards Waddle | 0.3 mi | |
| Keep left at the fork | 100 feet | |
| Turn left onto Grays Woods Boulevard | 0.2 mi | |
| Continue onto Skytop Mountain Road | 0.3 mi | |
| Turn right onto Stevenson Road | 1.0 mi | |
| Turn right onto Buffalo Run Road (PA 550) | 3.6 mi | |
| Turn left onto Fillmore Road | 0.8 mi | |
| Turn right onto Valley View Road | 3.4 mi | |
| You have arrived at your destination, on the left |
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Pendleton, South Carolina - Pennsylvania