I 80, Dwight D. Eisenhower Highway
2,882.9 mi1 day 17 hours 19 mins
| Head west on Market Street | 100 feet | |
| Make a slight right onto East Penn Square (PA 611) | 200 feet | |
| Make a slight left to stay on East Penn Square (PA 611) | 300 feet | |
| Continue onto John F. Kennedy Boulevard | 800 feet | |
| Turn right onto North 16th Street | 0.4 mi | |
| Take the ramp on the right towards I 676 West: International Airport | 0.2 mi | |
| Merge left onto Vine Street Expressway (I 676 W) | 1.0 mi | |
| Merge right onto Schuylkill Expressway (I 76 W) | 17.5 mi | |
| Keep left towards I 76 West: Harrisburg | 0.4 mi | |
| Merge left onto Pennsylvania Turnpike (I 76 W) | 295.8 mi | |
| Keep right onto Pennsylvania Turnpike (I 76 W) | 31.2 mi | |
| Continue onto Ohio Turnpike (I 76 W) | 6.9 mi | |
| Keep left onto Ohio Turnpike (I 76 W) | 72.5 mi | |
| Go straight towards I 71 North: Cleveland | 0.6 mi | |
| Merge left onto I 71 N | 5.1 mi | |
| Take the ramp towards I 480: Airport - Toledo | 0.4 mi | |
| Keep left at the fork | 0.6 mi | |
| Merge left onto Outerbelt South Freeway (I 480 W) | 9.4 mi | |
| Keep right onto I 480 W | 1.2 mi | |
| Merge left onto Ohio Turnpike (I 80 W) | 151.1 mi | |
| Continue onto Indiana Toll Road (I 80) | 107.1 mi | |
| Take exit 49 towards SR 39: La Porte | 0.6 mi | |
| Make a slight right | 200 feet | |
| Continue slightly right onto SR 39 | 1.2 mi | |
| Turn left onto US 20 | 3.9 mi | |
| Take the ramp towards I 94 West: Chicago | 0.2 mi | |
| Merge left onto I 94 W | 41.2 mi | |
| Continue onto Tri-State Tollway (I 80) | 6.1 mi | |
| Keep right towards I 80 West: Iowa | 0.3 mi | |
| Keep left onto I 80 | 144.8 mi | |
| Take the ramp towards I 80 West: Davenport | 6.7 mi | |
| Keep left onto I 80 | 186.3 mi | |
| Take the ramp towards I 80 West: Council Bluffs | 118.9 mi | |
| Keep left towards I 80 West: Council Bluffs | 933.4 mi | |
| Keep left onto I 80 | 0.5 mi | |
| Keep right towards UT 201 East: 2100 South | 0.6 mi | |
| Keep left at the fork | 1.1 mi | |
| Merge left onto Dwight D. Eisenhower Highway (I 15 N) | 1.3 mi | |
| Take the ramp towards I-80 W: Reno | 164.8 mi | |
| Keep left onto Dwight D. Eisenhower Highway (I 80) | 365.3 mi | |
| Continue onto Alan S. Hart Freeway (I 80 W) | 109.0 mi | |
| Keep left onto North Sacramento Beltline Freeway (I 80 W) | 54.3 mi | |
| Keep left onto I 80 W | 30.6 mi | |
| Keep left onto Eastshore Freeway (I 80 W) | 1.2 mi | |
| Keep right onto Eastshore Freeway (I 80 W) | 0.2 mi | |
| Keep right towards I 80: San Francisco | 0.7 mi | |
| Keep left onto I 80 W | 6.1 mi | |
| Continue onto James Lick Freeway (I 80 W) | 1.0 mi | |
| Take exit 1C towards Civic Center | 0.2 mi | |
| Keep right towards 9th Street | 300 feet | |
| Continue onto Harrison Street | 600 feet | |
| Turn right onto 9th Street | 0.5 mi | |
| Continue onto Hayes Street | 1,000 feet | |
| Turn left onto Van Ness Avenue (US 101 S) | 100 feet | |
| You have arrived at your destination, on the left |
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Philadelphia, Pennsylvania - San Francisco, California