US 23, I 75 $north
379.4 mi6 hours 47 mins
| Head north on Hambley Boulevard | 1.0 mi | |
| Turn right onto Loraine Street (KY 1384) | 900 feet | |
| Turn left onto North Mayo Trail (KY 1460) | 0.4 mi | |
| Take the ramp on the right | 900 feet | |
| Continue onto US 23 | 88.8 mi | |
| Continue onto Walnut Street (US 23) | 1.2 mi | |
| Continue onto Center Street (US 23) | 0.8 mi | |
| Continue onto Winchester Avenue (US 23) | 2.0 mi | |
| Keep right onto US 23 | 1.6 mi | |
| Turn left onto 14th Street | 400 feet | |
| Turn right onto Winchester Avenue | 400 feet | |
| Turn right onto 13th Street | 200 feet | |
| Continue onto Simeon Willis Memorial Bridge | 0.4 mi | |
| Take the ramp on the left | 400 feet | |
| Merge right onto US 52 W | 24.0 mi | |
| Take the ramp towards SR 823 North: Chillicothe | 16.3 mi | |
| Take the ramp towards US 23 North: Chillicothe | 0.5 mi | |
| Merge left onto US 23 | 33.6 mi | |
| Keep right towards US 23 North: Columbus | 37.2 mi | |
| Take the ramp towards I 270: Columbus | 0.3 mi | |
| Keep left at the fork | 0.7 mi | |
| Merge left onto Jack Nicklaus Freeway (I 270 W) | 1.3 mi | |
| Take exit 55 towards I 71: Cincinnati | 0.2 mi | |
| Keep right towards I 71 North: Columbus | 0.7 mi | |
| Merge left onto South Freeway (I 71 N) | 4.0 mi | |
| Continue onto West Innerbelt (SR 315 N) | 1.4 mi | |
| Continue onto Olentangy Freeway (SR 315 N) | 11.0 mi | |
| Continue slightly right onto Olentangy River Road (SR 315) | 3.9 mi | |
| Enter the roundabout and take the 2nd exit onto Olentangy River Road (SR 315) | 100 feet | |
| Exit the roundabout onto Olentangy River Road (SR 315) | 5.8 mi | |
| Turn left onto Columbus Pike (US 23) | 39.7 mi | |
| Keep left onto US 23 | 8.5 mi | |
| Take the ramp onto US 23 | 7.5 mi | |
| Continue onto SR 15 W | 17.4 mi | |
| Merge left onto I 75 N | 34.9 mi | |
| Keep right towards I 75 North: Toledo | 9.4 mi | |
| Take exit 201B towards SR 25 North: Downtown | 0.7 mi | |
| Merge right onto Anthony Wayne Trail (SR 25) | 600 feet | |
| Continue slightly left onto South Erie Street (SR 25) | 0.9 mi | |
| Turn left onto Cherry Street (SR 25) | 0.2 mi | |
| Turn right onto Greenbelt Parkway (SR 25) | 1.4 mi | |
| Take the ramp towards I 280 North | 0.4 mi | |
| Merge left onto I 280 N | 0.8 mi | |
| Keep right towards I 75 North: Detroit | 0.6 mi | |
| Continue slightly right onto I 75 N | 16.9 mi | |
| Take exit 14 towards Elm Avenue | 0.2 mi | |
| Continue right onto East Elm Avenue | 1.9 mi | |
| Turn left onto North Monroe Street (M 125) | 900 feet | |
| You have arrived at your destination |
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Pikeville, Kentucky - Monroe, Michigan