I 12 $west, I 49 $north
301.5 mi5 hours 6 mins
| Head north on South Strahan Street | 0 feet | |
| Turn right onto West North Street | 500 feet | |
| Turn right onto South Main Street | 2.6 mi | |
| Take the ramp on the right | 0.2 mi | |
| Merge left onto I 59 S | 38.0 mi | |
| Keep right towards I 12 West: Hammond | 0.5 mi | |
| Continue onto I 12 W | 82.0 mi | |
| Take the ramp towards US 61 North | 0.5 mi | |
| Merge left onto Airline Highway (US 61) | 7.0 mi | |
| Keep right onto Airline Highway (US 61) | 10.6 mi | |
| Continue onto US 190 W | 5.3 mi | |
| Continue onto US 190 | 1.2 mi | |
| Continue onto Airline Highway (US 190 W) | 39.2 mi | |
| Take the ramp | 0.3 mi | |
| Merge left onto I 49 N | 64.8 mi | |
| Continue onto I 49 N | 42.9 mi | |
| Take the ramp | 0.4 mi | |
| Make a slight right | 200 feet | |
| Go straight onto State Route 120 | 1.0 mi | |
| Turn left onto LA 1 | 4.3 mi | |
| Turn right | 0.4 mi | |
| Turn right onto Sowell Street | 500 feet | |
| Turn right onto Johnson Loop | 0.2 mi | |
| You have arrived at your destination |
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Poplarville, Mississippi - Natchez, Louisiana