US 301, I 95 $north
333.7 mi5 hours 49 mins
| Head southwest on US 19 | 900 feet | |
| Make a U-turn and continue on US 19 | 66.7 mi | |
| Take the ramp onto FL 121 | 20.3 mi | |
| Turn left onto Southwest 7th Street (US 41) | 0.7 mi | |
| Make a slight right onto US 41 | 500 feet | |
| Merge left onto West Noble Avenue (US 41) | 0.5 mi | |
| Turn left onto Main Street (US 27) | 0.4 mi | |
| Make a slight right onto FL 121 | 18.8 mi | |
| Continue onto Southeast Williston Road (FL 331) | 2.1 mi | |
| Continue onto Southeast 11th Street (FL 24A) | 0.7 mi | |
| Continue onto Waldo Road (FL 24) | 13.5 mi | |
| Merge left onto Sid Martin Highway (US 301) | 14.6 mi | |
| Go straight onto US 301 | 21.7 mi | |
| Take the ramp on the left | 0.2 mi | |
| Merge left onto I 10 E | 12.6 mi | |
| Take the ramp towards I-295: Daytona Beach | 0.2 mi | |
| Keep left towards I-295: Daytona Beach | 0.6 mi | |
| Merge left onto I 295 N | 14.2 mi | |
| Take the ramp on the left towards I 95 North: International Airport | 0.5 mi | |
| Merge left onto I 95 N | 118.5 mi | |
| Take the ramp towards I 16 East: Savannah | 0.6 mi | |
| Merge left onto I 16 E | 7.6 mi | |
| Keep left onto I 16 E | 0.6 mi | |
| Continue towards Savannah | 0.4 mi | |
| Go straight onto Montgomery Street | 300 feet | |
| Turn right onto West Liberty Street | 0.8 mi | |
| Turn left onto Randolph Street | 0.2 mi | |
| Turn right onto East President Street | 2.4 mi | |
| Continue onto Islands Expressway | 13.5 mi | |
| Continue onto Butler Avenue (US 80) | 0.3 mi | |
| You have arrived at your destination |
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Port Richey, Florida - Tybee Island, Georgia