US 64, I 55 $south
418.3 mi7 hours 29 mins
| Head southeast on Prim Road (AR 263) | 6.2 mi | |
| Turn left onto Greers Ferry Road (Hwy 92) | 5.9 mi | |
| Turn left onto Heber Springs Road North (AR 5) | 7.4 mi | |
| Turn right onto Floral Road (Hwy 87) | 4.3 mi | |
| Turn left onto Floral Road (Hwy 87) | 12.0 mi | |
| Continue onto Blackland Road (AR 157) | 0.3 mi | |
| Turn right onto Batesville Boulevard (US 167) | 17.9 mi | |
| Keep left onto US 64 | 37.3 mi | |
| Turn right onto AR 193 | 4.1 mi | |
| Continue onto Hwy 193 | 0.5 mi | |
| Continue onto AR 193 | 3.5 mi | |
| Turn left onto Old Military Rd West (AR 306) | 4.4 mi | |
| Turn right onto South Main (Hwy 1) | 5.3 mi | |
| Continue onto Washington Street (AR 1B) | 2.0 mi | |
| Take the ramp on the right | 0.2 mi | |
| Merge left onto I 40 N | 36.8 mi | |
| Continue onto I 40 | 1.3 mi | |
| Continue onto I 40 E | 0.8 mi | |
| Take the ramp towards I 55 South: Memphis | 0.5 mi | |
| Keep left onto I 55 E | 1.2 mi | |
| Continue onto I 55 | 3.5 mi | |
| Take the ramp towards I 55 South: Jackson Mississippi | 6.0 mi | |
| Continue onto I 55 S | 204.5 mi | |
| Keep left towards I 55 South: McComb | 49.5 mi | |
| Take the ramp | 700 feet | |
| Keep left at the fork | 300 feet | |
| Turn left onto Dunn-Ratcliff Road Northwest | 500 feet | |
| Continue onto Union St Extended Northeast | 1.0 mi | |
| Turn right onto US 51 | 0.7 mi | |
| Turn left onto MS 550 | 0.4 mi | |
| Turn right onto Schwem Avenue (MS 550) | 700 feet | |
| Continue left onto West Monticello Street (MS 550) | 0.4 mi | |
| You have arrived at your destination |
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Prim, Arkansas - Brookhaven, Mississippi