I 81 $north, I 64 $east; I 81 $north
214.3 mi3 hours 22 mins
| Head north on South Jefferson Street | 100 feet | |
| Turn right onto Campbell Avenue Southeast (US 11) | 900 feet | |
| Turn left onto Williamson Road Southeast (US 11) | 300 feet | |
| Continue onto Williamson Road Northeast (US 11) | 0.2 mi | |
| Take the ramp towards I 581 North: Lexington | 0.3 mi | |
| Merge left onto I 581 N | 5.6 mi | |
| Keep right towards I 81 North: Lexington | 14.2 mi | |
| Continue onto I 81 N | 157.8 mi | |
| Take the ramp towards VA 7: Winchester | 0.2 mi | |
| Keep left at the fork | 300 feet | |
| Turn left onto Berryville Pike (VA 7) | 3.5 mi | |
| Continue onto Harry Flood Byrd Memorial Highway (VA 7) | 17.9 mi | |
| Continue onto Harry Flood Byrd Highway (VA 7) | 4.3 mi | |
| Take the ramp towards VA 287: Purcellville | 0.3 mi | |
| Turn left onto Berlin Turnpike (VA 287) | 8.8 mi | |
| Continue onto South Berlin Pike (VA 287) | 0.9 mi | |
| Turn right onto South Church Street (SR 1501) | 500 feet | |
| Turn right onto East Pennsylvania Avenue | 0 feet | |
| You have arrived at your destination |
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Roanoke, Virginia - Lovettsville, Virginia