I 81 $south, I 77 $south
100.6 mi1 hour 40 mins
| Head north on South Jefferson Street | 100 feet | |
| Turn right onto Campbell Avenue Southeast (US 11) | 900 feet | |
| Turn left onto Williamson Road Southeast (US 11) | 300 feet | |
| Continue onto Williamson Road Northeast (US 11) | 0.2 mi | |
| Take the ramp towards I 581 North: Lexington | 0.3 mi | |
| Merge left onto I 581 N | 5.6 mi | |
| Keep left towards I 81 South: Salem | 0.5 mi | |
| Merge right onto I 81 S | 61.9 mi | |
| Take the ramp towards I 77 South: Charlotte NC | 0.4 mi | |
| Continue towards I 77 South: Charlotte NC | 0.4 mi | |
| Continue onto I 77 S | 23.1 mi | |
| Take the ramp towards VA 148: Fancy Gap | 0.3 mi | |
| Turn left onto Chance Creek Road (SR 148) | 300 feet | |
| Continue onto VA 148 | 0.8 mi | |
| Turn right onto Fancy Gap Highway (US 52) | 6.8 mi | |
| You have arrived at your destination |
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Roanoke, Virginia - Cana, Virginia