How to get from Roanoke, Virginia to Charleston, South Carolina

Discover, print or download the driving directions for the best route to go from Roanoke, Virginia to Charleston, South Carolina.

Enlarge the route map Roanoke, Virginia - Charleston, South Carolina

Driving directions from Roanoke, Virginia to Charleston, South Carolina

I 77 $south, I 26 $east

404.6 mi6 hours 17 mins

Head north on South Jefferson Street 100 feet
Turn right onto Campbell Avenue Southeast (US 11) 900 feet
Turn left onto Williamson Road Southeast (US 11) 300 feet
Continue onto Williamson Road Northeast (US 11) 0.2 mi
Take the ramp towards I 581 North: Lexington 0.3 mi
Merge left onto I 581 N 5.6 mi
Keep left towards I 81 South: Salem 0.5 mi
Merge right onto I 81 S 61.9 mi
Take the ramp towards I 77 South: Charlotte NC 0.4 mi
Continue towards I 77 South: Charlotte NC 0.4 mi
Continue onto I 77 S 100.6 mi
Keep right onto I 77 S 109.4 mi
Keep left onto I 77 S 18.4 mi
Keep left towards I 26 South: Charleston 0.8 mi
Merge right onto I 26 E 104.3 mi
Take the ramp on the left towards Visitor Center 0.4 mi
Turn right onto Meeting Street (US 52) 1.2 mi
You have arrived at your destination

Print directions
Roanoke, Virginia - Charleston, South Carolina

At How to get from we offer the best route to any destination. We use the most advanced technologies of maps representation, route calculation, traffic information updated in real time and distance calculator to give you a detailed itinerary to get to your destination.