I 95 $north, I 73 $north; I 74 $west; US 220 $north
303.2 mi5 hours 12 mins
| Head west on Ball Park Road | 1.0 mi | |
| Turn left onto Sea Island Parkway (US 21) | 6.8 mi | |
| Continue onto Richard V Woods Memorial Bridge (US 21 Business) | 0.4 mi | |
| Continue onto Carteret Street (US 21 Business) | 0.7 mi | |
| Continue slightly left onto Boundary Street (US 21 Business) | 3.0 mi | |
| Continue onto Trask Parkway (US 21) | 12.0 mi | |
| Enter the roundabout and take the 1st exit onto US 21 | 200 feet | |
| Exit the roundabout onto US 21 | 6.5 mi | |
| Continue onto Castle Hall Road (US 17) | 0.3 mi | |
| Continue onto Kings Highway (US 17) | 1.4 mi | |
| Take the ramp towards I 95 North: Florence | 0.3 mi | |
| Merge left onto I 95 N | 130.9 mi | |
| Take the ramp towards US 52: Florence | 800 feet | |
| Keep right at the fork | 600 feet | |
| Merge left onto West Lucas Street (US 52) | 1.5 mi | |
| Continue onto South Main Street (US 52) | 3.4 mi | |
| Continue straight to stay on South Main Street (US 52 Business) | 1.6 mi | |
| Turn right onto Pearl Street (SC 34) | 200 feet | |
| Turn left onto Exchange Street (SC 34) | 200 feet | |
| Turn right onto Cashua Street (SC 34) | 0.9 mi | |
| Turn left onto Society Hill Road | 13.4 mi | |
| Keep right onto Church Street | 1.0 mi | |
| Make a slight right onto Cheraw Highway (US 52) | 13.5 mi | |
| Merge left onto Market Street (US 1) | 0.9 mi | |
| Turn left onto 2nd Street (US 1) | 0.4 mi | |
| Turn right onto US 1 | 1.9 mi | |
| Turn left onto US 1 | 17.3 mi | |
| Keep left onto US 220 | 82.6 mi | |
| Go straight onto Randleman Road | 400 feet | |
| Merge left onto Freeman Mill Road | 0.7 mi | |
| Take the ramp towards McGee Street | 500 feet | |
| You have arrived at your destination |
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Saint Helena Island - Greensboro, North Carolina