I 70 $east; US 40 $east, I 55 $south
380.8 mi5 hours 53 mins
| Head west | 200 feet | |
| Turn right onto Broadmoor Street | 200 feet | |
| Turn left onto Martway Street | 300 feet | |
| Turn right onto Metcalf Avenue (US 69 N) | 1.3 mi | |
| Keep right towards I 35 North: Des Moines | 1.2 mi | |
| Keep left towards I 35 North: Des Moines | 5.1 mi | |
| Take exit 2U towards I 70 East: Saint Louis | 400 feet | |
| Keep right towards I 70 East: Saint Louis | 200 feet | |
| Keep left towards I 70 East: Saint Louis | 0.4 mi | |
| Merge left onto I 670 E | 0.5 mi | |
| Keep left towards I 70 East: Saint Louis | 0.4 mi | |
| Merge left onto Truman/Eisenhower Presidential Highway (I 70 E) | 29.1 mi | |
| Continue onto I 70 E | 69.3 mi | |
| Keep left onto I 70 E | 108.5 mi | |
| Take exit 210A towards I 64 East: Chesterfield | 25.3 mi | |
| Take exit 25 towards I 270: Chicago | 0.3 mi | |
| Keep right towards I 270 South: Memphis | 0.3 mi | |
| Merge left onto I 270 S | 11.5 mi | |
| Take exit 1A towards I 55: Saint Louis | 0.4 mi | |
| Keep right towards I 55 South: Memphis | 0.4 mi | |
| Merge left onto I 55 S | 102.7 mi | |
| Keep left onto I 55 S | 1.7 mi | |
| Take exit 91 towards MO AB: Cape Girardeau Regional Airport | 1,000 feet | |
| Keep right towards MO AB: Cape Girardeau Regional Airport | 200 feet | |
| Turn right onto MO AB | 5.6 mi | |
| Enter the roundabout and take the 2nd exit towards MO 25 South: Delta | 200 feet | |
| Exit the roundabout towards MO 25 South: Delta | 15.8 mi | |
| Turn right onto 91 | 0.3 mi | |
| You have arrived at your destination |
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Shawnee Mission, City of Mission, Kansas - Advance, Missouri