I 40, I 81 $north
357.2 mi5 hours 58 mins
| Head north on Public Square East | 0 feet | |
| Continue onto North Main Street | 2.6 mi | |
| Continue onto Florida Short Route (US 231) | 3.6 mi | |
| Continue onto Florida Short Rte (US 231) | 5.7 mi | |
| Continue onto Shelbyville Highway (US 231) | 8.6 mi | |
| Continue onto South Church Street (US 231) | 2.7 mi | |
| Turn left | 0.4 mi | |
| Merge left onto I 24 W | 5.9 mi | |
| Take exit 74B towards 840: Lebanon | 0.6 mi | |
| Merge left onto State Route 840 (I 840 E) | 23.0 mi | |
| Keep right towards I 40 East: Knoxville | 0.7 mi | |
| Merge left onto I 40 | 185.6 mi | |
| Keep left towards I 81 North: Bristol | 56.6 mi | |
| Take exit 57A towards I 26 East: Johnson City | 0.4 mi | |
| Merge left onto I 26 E | 11.4 mi | |
| Continue onto I 26 E | 3.7 mi | |
| Take the ramp towards US 321: Elizabethton | 700 feet | |
| Keep right at the fork | 400 feet | |
| Merge left onto University Parkway (US 321) | 500 feet | |
| Continue onto US 321 N | 3.8 mi | |
| Continue onto West Elk Avenue (US 321) | 3.6 mi | |
| Keep right onto W Elk Ave | 0.3 mi | |
| Continue onto East Elk Avenue | 0.3 mi | |
| Turn right onto South Sycamore Street | 0.7 mi | |
| Turn right onto Veterans Memorial Parkway (US 19E) | 2.3 mi | |
| Continue onto Rod Swift Bridge (US 19E) | 2.0 mi | |
| Turn left onto US 321 | 9.6 mi | |
| Turn right onto US 321 | 22.5 mi | |
| Make a slight left | 300 feet | |
| Go straight onto Old US 421 | 600 feet | |
| You have arrived at your destination |
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Shelbyville, Tennessee - Sugar Grove, North Carolina