How to get from Sioux Falls, South Dakota to St Louis, Missouri

Discover, print or download the driving directions for the best route to go from Sioux Falls, South Dakota to St Louis, Missouri.

Enlarge the route map Sioux Falls, South Dakota - St Louis, Missouri

Driving directions from Sioux Falls, South Dakota to St Louis, Missouri

I 29 $south, I 70 $east; US 40 $east

610.0 mi9 hours

Head south on South Minnesota Avenue (I 229 Business S) 2.4 mi
Take the ramp on the right onto I 229 Business 0.2 mi
Merge left onto I 229 S 4.2 mi
Merge left onto I 29 S 177.8 mi
Keep right towards I 29 South: Kansas City 156.2 mi
Merge right onto I 29 S 2.3 mi
Keep left towards I 29 South: Kansas City 14.6 mi
Merge left onto I 29 S 4.4 mi
Keep left towards I 70 East: Saint Louis 30.2 mi
Continue onto I 70 E 69.3 mi
Keep left onto I 70 E 108.5 mi
Take exit 210A towards I 64 East: Chesterfield 39.4 mi
Take exit 39A towards 14th Street 0.2 mi
Turn left onto South 14th Street 0.3 mi
Turn right onto Market Street 500 feet
You have arrived at your destination

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Sioux Falls, South Dakota - St Louis, Missouri

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