I 65 $south, I 75 $south
1,446.1 mi22 hours 55 mins
| Head southwest on State Highway 42 (WI 42) | 0 feet | |
| Turn left onto State Highway 57 (WI 57) | 27.1 mi | |
| Turn left onto State Highway 42/57 (WI 42) | 10.8 mi | |
| Continue onto State Highway 57 (WI 57) | 33.6 mi | |
| Take the ramp towards I 43 South: Milwaukee | 0.5 mi | |
| Merge left onto I 43 S | 119.0 mi | |
| Keep left towards WIS 94 East: Layton Ave | 33.7 mi | |
| Keep right towards Chicago | 24.4 mi | |
| Keep left towards I 94 East Toll: Chicago | 1.0 mi | |
| Keep left onto Edens Spur (I 94 E) | 3.8 mi | |
| Continue onto Edens Expressway (I 94 E) | 13.2 mi | |
| Keep right onto Edens Expressway (I 94 E) | 0.6 mi | |
| Merge left onto Kennedy Expressway (I 90) | 8.1 mi | |
| Continue onto Dan Ryan Expressway (I 90) | 2.4 mi | |
| Keep left towards I 90 Express | 3.8 mi | |
| Take the ramp towards I 90 East: Chicago Skyway | 0.4 mi | |
| Merge right onto Dan Ryan Expressway (I 90) | 0.5 mi | |
| Keep left towards I 90 East: Chicago Skyway | 10.6 mi | |
| Keep left onto Indiana Toll Road (I 90) | 11.3 mi | |
| Take the ramp towards IN 53 | 0.3 mi | |
| Turn right onto Broadway (SR 53) | 0.2 mi | |
| Turn left onto East 5th Avenue (US 12) | 1.6 mi | |
| Turn right onto I 65 S | 132.7 mi | |
| Keep left onto I 65 S | 299.6 mi | |
| Keep left towards I 24 East: Nashville | 2.4 mi | |
| Keep left towards I 24 East: Chattanooga | 2.8 mi | |
| Keep left towards I 40 East: Knoxville | 2.1 mi | |
| Keep right towards I 24 East: Chattanooga | 0.8 mi | |
| Keep left onto I 24 E | 133.0 mi | |
| Keep right towards Atlanta | 0.4 mi | |
| Merge left onto I 75 S | 111.0 mi | |
| Continue onto James Wendell George Parkway (I 75 S) | 2.3 mi | |
| Keep left onto I 75 S | 64.9 mi | |
| Take the ramp towards I 475 South: Valdosta | 15.6 mi | |
| Keep left towards I 75 South: Valdosta | 0.6 mi | |
| Merge left onto I 75 S | 300.1 mi | |
| Keep right towards I 75 South: Tampa | 53.5 mi | |
| Keep right towards I 275 South: Airport | 15.9 mi | |
| Take the ramp towards Downtown East-West | 0.6 mi | |
| Keep left towards Downtown East | 900 feet | |
| Continue onto North Orange Avenue | 0.3 mi | |
| Turn right onto East Cass Street | 0.3 mi | |
| Turn left onto North Ashley Drive | 0.3 mi | |
| Make a U-turn and continue on North Ashley Drive | 100 feet | |
| You have arrived at your destination |
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Sister Bay, Wisconsin - Tampa, Florida