Crisfield Highway, Sussex Highway
125.7 mi2 hours 30 mins
| Head northeast on Broad Street | 300 feet | |
| Turn right onto North 11th Street | 200 feet | |
| Turn left onto West Main Street (MD 413) | 0.3 mi | |
| Continue onto Richardson Avenue (MD 413) | 1.2 mi | |
| Continue onto Crisfield Highway (MD 413) | 12.9 mi | |
| Take the ramp | 400 feet | |
| Merge right onto Ocean Highway (US 13) | 11.8 mi | |
| Continue onto South Fruitland Boulevard (US 13) | 0.3 mi | |
| Continue onto Salisbury Bypass (US 13 N) | 10.8 mi | |
| Take the ramp towards US 13 North: Salisbury | 0.3 mi | |
| Keep right towards US 13 North: Dover | 0.2 mi | |
| Merge left onto North Salisbury Boulevard (US 13) | 0.8 mi | |
| Keep right onto North Salisbury Boulevard (US 13) | 3.1 mi | |
| Continue onto Sussex Highway (US 13) | 21.4 mi | |
| Turn left onto East Newton Road (DE 404) | 2.1 mi | |
| Turn right onto Seashore Highway (DE 404) | 6.1 mi | |
| Continue onto Shore Highway (MD 404) | 17.3 mi | |
| Continue onto Queen Anne Highway (MD 404 W) | 6.2 mi | |
| Take the ramp | 600 feet | |
| Merge left onto Ocean Gateway (US 50) | 6.6 mi | |
| Keep right onto US 50 | 0.8 mi | |
| Merge left onto Blue Star Memorial Highway (US 50) | 20.7 mi | |
| Take the ramp towards MD 70 South: Roscoe Rowe Boulevard | 0.3 mi | |
| Continue onto Roscoe Rowe Boulevard (MD 70) | 1.4 mi | |
| Keep right onto Roscoe Rowe Boulevard | 700 feet | |
| Turn left onto Northwest Street | 800 feet | |
| Enter Church Circle and take the 4th exit onto Duke of Gloucester Street | 400 feet | |
| Exit the roundabout onto Duke of Gloucester Street | 900 feet | |
| You have arrived at your destination |
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Smith Island, Maryland - Annapolis, Maryland