US 65 $south, US 65
215.6 mi4 hours 23 mins
| Head east on Park Central East | 500 feet | |
| Continue onto East Saint Louis Avenue | 0.8 mi | |
| Turn left onto North National Avenue | 400 feet | |
| Turn right onto East Trafficway Street | 1.2 mi | |
| Go straight onto East Chestnut Expressway (US 65 Business) | 1.5 mi | |
| Take the ramp towards US 65 South | 0.3 mi | |
| Merge left onto Schoolcraft Freeway (US 65 S) | 66.8 mi | |
| Continue onto US 62 | 4.4 mi | |
| Turn left onto Arkmo Drive (US 62) | 69.4 mi | |
| Continue onto US 65 | 38.1 mi | |
| Take the ramp on the left onto US 65 S | 28.0 mi | |
| Take the ramp onto US 65 S | 2.8 mi | |
| Take the ramp towards I 630 | 0.4 mi | |
| Continue onto Wilbur D. Mills Freeway (I 630 W) | 1.4 mi | |
| Take the ramp | 900 feet | |
| Turn right onto Dr Martin Luther King Drive | 200 feet | |
| Turn left onto West 7th Street | 400 feet | |
| Turn right onto State Capitol | 500 feet | |
| Make a slight right | 300 feet | |
| You have arrived at your destination |
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Springfield, Missouri - Littlerock, Arkansas