I 55 $south, US 49
659.5 mi11 hours 41 mins
| Head east on Park Central East | 500 feet | |
| Continue onto East Saint Louis Avenue | 0.8 mi | |
| Turn left onto North National Avenue | 400 feet | |
| Turn right onto East Trafficway Street | 1.2 mi | |
| Go straight onto East Chestnut Expressway (US 65 Business) | 1.5 mi | |
| Take the ramp towards US 65 South | 0.3 mi | |
| Merge left onto Schoolcraft Freeway (US 65 S) | 5.5 mi | |
| Take the ramp towards US 60 East: Cabool | 0.2 mi | |
| Merge left onto US 60 E | 68.7 mi | |
| Continue onto US 60 | 12.9 mi | |
| Continue onto US 60 E | 0.5 mi | |
| Keep right towards US 63 South: West Plains | 58.0 mi | |
| Make a slight left onto US 63 | 3.4 mi | |
| Turn left onto US 63 | 1.5 mi | |
| Turn left onto East Main Street (US 62) | 27.3 mi | |
| Keep left onto US 63 | 78.0 mi | |
| Take the ramp towards I 55 South: Memphis | 0.6 mi | |
| Merge left onto I 55 S | 13.3 mi | |
| Continue onto I 55 E | 3.1 mi | |
| Merge left onto I 40 | 1.4 mi | |
| Continue onto I 40 E | 0.8 mi | |
| Take the ramp towards I 55 South: Memphis | 0.5 mi | |
| Keep left onto I 55 E | 1.2 mi | |
| Continue onto I 55 | 3.5 mi | |
| Take the ramp towards I 55 South: Jackson Mississippi | 6.0 mi | |
| Continue onto I 55 S | 202.2 mi | |
| Take the ramp towards I 20 East: Meridian | 0.9 mi | |
| Keep right onto US 49 S | 77.8 mi | |
| Continue onto US 49 | 4.8 mi | |
| Take the ramp towards I 59 South: New Orleans | 0.3 mi | |
| Merge left towards Mississippi Gulf Coast | 7.8 mi | |
| Take the ramp towards US 98 East: Lucedale | 3.2 mi | |
| Take the ramp towards US 49: Wiggins | 0.3 mi | |
| Keep left towards Multi Purpose Center | 800 feet | |
| Turn right onto US 49 | 42.0 mi | |
| Take the ramp | 0.8 mi | |
| Continue onto MS 67 S | 20.5 mi | |
| Continue onto I 110 S | 700 feet | |
| Take exit 4A towards I 10 East: Pascagoula | 0.3 mi | |
| Keep left towards I 10 | 0.3 mi | |
| Merge left onto I 10 | 2.6 mi | |
| Take the ramp towards MS 609: Ocean Springs | 0.2 mi | |
| Keep right at the fork | 600 feet | |
| Go straight onto Washington Avenue (MS 609) | 2.9 mi | |
| Turn left onto Government Street | 1.7 mi | |
| Turn right onto Twin Oaks Drive | 0 feet | |
| You have arrived at your destination |
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Springfield, Missouri - Ocean Springs, Mississippi