I 81 $north, New York State Thruway
338.1 mi5 hours 26 mins
| Head west on East Springfield Road | 2.0 mi | |
| Go straight onto Sproul Road (PA 320) | 1.2 mi | |
| Turn right onto Lawrence Road | 1.5 mi | |
| Turn left onto West Chester Pike (PA 3 W) | 200 feet | |
| Take the ramp towards I 476 North: Plymouth Meeting | 0.4 mi | |
| Merge left onto Mid County Expressway (I 476 N) | 10.6 mi | |
| Keep right onto Mid County Expressway (I 476 N) | 800 feet | |
| Continue onto Pennsylvania Turnpike Northeast Extension (I 476 N) | 110.7 mi | |
| Continue towards I 81: Clarks Summit | 0.8 mi | |
| Keep right towards I 81: Binghamton | 0.3 mi | |
| Keep left towards Binghamton | 0.3 mi | |
| Merge left onto I 81 N | 47.5 mi | |
| Continue onto I 81 W | 4.5 mi | |
| Keep right towards I 81 North: Syracuse | 1.8 mi | |
| Keep left towards I 81 North: Syracuse | 70.1 mi | |
| Take the ramp towards I 690 West: Fairgrounds | 0.2 mi | |
| Merge right towards Fairgrounds | 8.6 mi | |
| Take the ramp towards I 90 | 0.2 mi | |
| Keep left towards I 90 | 0.5 mi | |
| Keep right towards I 90 West: Buffalo | 1,000 feet | |
| Merge left onto New York State Thruway (I 90 W) | 60.9 mi | |
| Take exit 45 towards I 490: Rochester | 0.4 mi | |
| Continue onto I 490 W | 14.8 mi | |
| Take the ramp towards Stadiums | 0.2 mi | |
| Turn right onto Spring Street | 400 feet | |
| Turn left onto South Plymouth Avenue | 0.2 mi | |
| You have arrived at your destination |
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Springfield, Pennsylvania - Rochester, New York