I 71 $south, I 65 $south
432.5 mi6 hours 39 mins
| Head west on East Main Street (US 40) | 0.7 mi | |
| Continue onto National Road West (US 40) | 0.7 mi | |
| Take the ramp on the right | 0.3 mi | |
| Merge left onto I 70 | 105.4 mi | |
| Take the ramp towards Cleveland | 0.2 mi | |
| Keep left towards I 270 South: Cincinnati | 0.3 mi | |
| Keep right towards I 270 South: Cincinnati | 0.4 mi | |
| Keep left at the fork | 0.6 mi | |
| Continue onto Jack Nicklaus Freeway (I 270 S) | 10.9 mi | |
| Take exit 55 towards I 71: Cincinnati | 0.2 mi | |
| Keep left towards I 71 South: Cincinnati | 0.3 mi | |
| Keep right towards I 71 South: Cincinnati | 0.3 mi | |
| Merge left onto South Freeway (I 71 S) | 65.4 mi | |
| Continue onto I 71 W | 3.5 mi | |
| Continue onto I 71 S | 30.7 mi | |
| Keep left onto Northeast Expressway (I 71 S) | 0.6 mi | |
| Continue onto Lytle Tunnel (I 71 S) | 1.5 mi | |
| Continue onto Brent Spence Bridge (I 71 S) | 18.8 mi | |
| Take the ramp towards I 71 South: Louisville | 77.3 mi | |
| Keep right towards I 65 South: Louisville | 1.0 mi | |
| Keep left at the fork | 600 feet | |
| Merge left onto I 65 S | 107.6 mi | |
| Take the ramp towards KY 446: Bowling Green | 0.5 mi | |
| Continue onto KY 446 W | 0.5 mi | |
| Keep left at the fork | 0.5 mi | |
| Go straight onto Louisville Road (US 31W) | 2.5 mi | |
| Continue onto Kentucky Street (US 68) | 0.5 mi | |
| Continue onto Adams Street (US 68 Business) | 0.6 mi | |
| Turn left onto East 12th Avenue | 500 feet | |
| Turn left onto Kentucky Street (US 68 Business) | 0.2 mi | |
| You have arrived at your destination |
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St. Clairsville, Ohio - Bowling Green, Kentucky