How to get from St. Petersburg, Florida to Key Largo, Florida

Discover, print or download the driving directions for the best route to go from St. Petersburg, Florida to Key Largo, Florida.

Enlarge the route map St. Petersburg, Florida - Key Largo, Florida

Driving directions from St. Petersburg, Florida to Key Largo, Florida

I 75 $south, Alligator Alley

300.9 mi4 hours 39 mins

Head north on 34th Street South (US 19) 0 feet
Make a U-turn and continue on 34th Street South (US 19) 1.8 mi
Turn left onto 26th Avenue South 300 feet
Take the ramp on the right 0.3 mi
Merge left onto I 275 S 17.7 mi
Keep left towards I 75 South: Naples 1.0 mi
Merge left onto I 75 S 28.1 mi
Keep left onto I 75 S 175.8 mi
Take the ramp towards US 27: Miami 0.2 mi
Keep right towards US 27 South: Miami 0.5 mi
Merge left onto US 27 17.8 mi
Take the ramp on the left towards Florida's Turnpike Toll South 0.3 mi
Merge left onto Homestead Extension of Florida's Turnpike 35.4 mi
Merge left onto Dixie Highway (US 1) 19.3 mi
Continue onto Overseas Highway (US 1) 2.3 mi
You have arrived at your destination

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St. Petersburg, Florida - Key Largo, Florida

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