I 75 $north, I 24 $west
1,501.6 mi22 hours 45 mins
| Head southeast on Southwest Flagler Avenue | 400 feet | |
| Turn right onto Southwest Saint Lucie Avenue | 100 feet | |
| Enter the roundabout and take the 2nd exit | 100 feet | |
| Exit the roundabout | 100 feet | |
| Continue slightly right onto Southwest Joan Jefferson Way | 400 feet | |
| Turn right onto Southwest Federal Highway (US 1) | 600 feet | |
| Continue onto Roosevelt Bridge (US 1) | 0.9 mi | |
| Continue onto Northwest Federal Highway (US 1) | 2.4 mi | |
| Continue onto Federal Highway (US 1) | 2.0 mi | |
| Turn left onto Southeast Port Saint Lucie Boulevard | 4.2 mi | |
| Turn left onto Southwest Bayshore Boulevard | 600 feet | |
| Take the ramp | 200 feet | |
| Continue straight | 0.5 mi | |
| Keep right towards Orlando | 0.3 mi | |
| Merge left onto Florida's Turnpike | 122.2 mi | |
| Keep left onto Florida's Turnpike | 43.0 mi | |
| Merge left onto I 75 N | 300.4 mi | |
| Take the ramp on the left towards I 475 North: Atlanta | 15.9 mi | |
| Merge right onto I 75 N | 49.5 mi | |
| Keep left towards I 75 North: Atlanta | 20.2 mi | |
| Continue onto James Wendell George Parkway (I 75 N) | 2.6 mi | |
| Keep right towards I 75 North: Marietta | 18.0 mi | |
| Keep left towards North I 75: Chattanooga | 88.1 mi | |
| Take the ramp on the left towards I 24 West: Chattanooga | 0.5 mi | |
| Continue towards Chattanooga | 133.2 mi | |
| Keep left onto I 24 W | 1.3 mi | |
| Keep left towards I 24West: Nashville | 2.2 mi | |
| Keep right towards I 24 West: Clarksville | 4.8 mi | |
| Keep left towards I 24 West: Clarksville | 112.6 mi | |
| Keep right onto I 24 W | 63.5 mi | |
| Keep left towards I 57 North: Chicago | 0.4 mi | |
| Merge left towards Mount Vernon | 51.7 mi | |
| Take the ramp on the left towards I 64 West: Saint Louis | 70.7 mi | |
| Take the ramp towards I 70 West: Kansas City | 0.7 mi | |
| Merge right onto I 70 W | 202.1 mi | |
| Take exit 49 towards MO 13: Higginsville | 0.2 mi | |
| Turn right onto MO 13 | 45.2 mi | |
| Turn left onto West Elm Street (MO 116) | 12.1 mi | |
| Keep right onto MO 116 | 0.3 mi | |
| Take the ramp on the right towards I 35 North: Cameron | 0.2 mi | |
| Merge left onto I 35 N | 107.0 mi | |
| Take the ramp towards US 34: Osceola | 0.3 mi | |
| Turn right onto US 34 | 1,000 feet | |
| Make a U-turn and continue on US 34 | 21.6 mi | |
| Turn left onto North Douglas Street (US 169) | 0.3 mi | |
| You have arrived at your destination |
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Stuart, Florida - Afton, Iowa