How to get from Tampa, Florida to Bluffton, South Carolina

Discover, print or download the driving directions for the best route to go from Tampa, Florida to Bluffton, South Carolina.

Enlarge the route map Tampa, Florida - Bluffton, South Carolina

Driving directions from Tampa, Florida to Bluffton, South Carolina

I 75 $north, I 95 $north

362.7 mi5 hours 50 mins

Head northwest on North Ashley Drive 0.4 mi
Take the ramp 0.2 mi
Keep right at the fork 800 feet
Merge left onto I 275 N 17.0 mi
Merge left onto I 75 N 82.5 mi
Take the ramp towards FL 326 0.2 mi
Make a slight right 100 feet
Merge left onto FL 326 2.6 mi
Turn left onto US 301 5.5 mi
Keep right towards North US 301: Starke 48.4 mi
Go straight onto US 301 21.7 mi
Take the ramp on the left 0.2 mi
Merge left onto I 10 E 12.6 mi
Take the ramp towards I-295: Daytona Beach 0.2 mi
Keep left towards I-295: Daytona Beach 0.6 mi
Merge left onto I 295 N 14.2 mi
Take the ramp on the left towards I 95 North: International Airport 0.5 mi
Merge left onto I 95 N 140.0 mi
Take the ramp towards US 278: Beaufort 0.3 mi
Keep right towards US 278 East: Beaufort 400 feet
Merge left onto Independence Boulevard (US 278) 6.0 mi
Continue onto Fording Island Road (US 278) 7.4 mi
Turn right onto Bluffton Road (SC 46) 0.8 mi
Enter the roundabout and take the 2nd exit onto Bluffton Road (SC 46) 200 feet
Exit the roundabout onto Bluffton Road (SC 46) 0.9 mi
Turn right onto May River Road (SC 46) 200 feet
You have arrived at your destination

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Tampa, Florida - Bluffton, South Carolina

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