I 70 $east; US 40 $east, I 64 $east
1,187.3 mi18 hours 14 mins
| Head south on Southeast Monroe Street | 500 feet | |
| Take the ramp | 0.2 mi | |
| Merge left onto Dwight D. Eisenhower Highway (I 70) | 3.1 mi | |
| Keep left towards I-70 East | 2.1 mi | |
| Merge right onto Kansas Turnpike (I 70) | 12.7 mi | |
| Take the ramp towards KS 10: Lecompton | 0.4 mi | |
| Keep right at the fork | 400 feet | |
| Merge left onto South Lawrence Trafficway (KS 10) | 36.4 mi | |
| Keep left towards I 435 East | 0.2 mi | |
| Merge left onto I 435 | 12.2 mi | |
| Keep left towards I 435 North: Des Moines | 9.1 mi | |
| Take exit 63B towards I 70 East: Saint Louis | 0.8 mi | |
| Keep left towards I 70 East: Saint Louis | 500 feet | |
| Merge left onto Truman/Eisenhower Presidential Highway (I 70 E) | 92.2 mi | |
| Keep left onto I 70 E | 142.4 mi | |
| Keep right onto I 70 E | 8.0 mi | |
| Take the ramp towards I 64 East: Louisville | 0.6 mi | |
| Merge left onto I 64 E | 70.1 mi | |
| Keep right towards I 57 South | 4.6 mi | |
| Take the ramp on the left towards I 64 East: Louisville | 257.0 mi | |
| Take exit 111 on the left towards I 64 East: Winchester | 16.6 mi | |
| Keep left onto I 64 E | 252.8 mi | |
| Continue onto I 77 S | 26.5 mi | |
| Keep left towards I 77 South: Roanoke | 8.7 mi | |
| Take the ramp towards I 77 South: Charlotte NC | 37.3 mi | |
| Take the ramp on the left towards I 74 East: Mount Airy | 12.7 mi | |
| Continue onto Pilot Mountain Parkway (US 52 S) | 30.7 mi | |
| Take the ramp towards I 40 Business East: Kernersville | 800 feet | |
| Merge left onto I 40 Business E | 2.0 mi | |
| Continue onto I 40 Business E | 11.2 mi | |
| Merge left onto I 40 | 4.8 mi | |
| Keep right onto I 40 | 7.8 mi | |
| Merge right onto I 40 | 1.8 mi | |
| Keep left onto I 40 | 36.7 mi | |
| Keep right towards I 40 East: Raleigh | 30.3 mi | |
| Keep right towards Wade Avenue | 3.3 mi | |
| Take the ramp towards I 440 East: Wake Forest | 0.2 mi | |
| Merge left onto I 440 E | 9.5 mi | |
| Take the ramp towards I 87 North: Wilson | 0.7 mi | |
| Continue onto I 87 N | 3.1 mi | |
| Continue onto I-87 | 13.7 mi | |
| Keep right onto US 264 E | 16.6 mi | |
| Take the ramp | 0.3 mi | |
| Go straight onto US 264 Alternate | 6.7 mi | |
| Continue onto Hines Street West | 0.8 mi | |
| Continue onto Hines Street Southwest | 500 feet | |
| You have arrived at your destination |
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Topeka, Kansas - Wilson, North Carolina