National Pike, National Freeway
151.5 mi2 hours 27 mins
| Head southeast on Union Street | 300 feet | |
| Turn left onto West Fayette Street (US 40 Business E) | 0.7 mi | |
| Go straight onto West Main Street (US 40 Business) | 0.5 mi | |
| Continue onto National Pike (US 40 Business) | 1.5 mi | |
| Keep left onto US 40 Business E | 0.3 mi | |
| Merge left onto US 40 E | 28.9 mi | |
| Take the ramp | 300 feet | |
| Merge left onto Garrett Highway (US 40) | 0.3 mi | |
| Take the ramp towards I 68 West | 0.4 mi | |
| Merge left onto National Freeway (I 68 E) | 66.5 mi | |
| Keep right towards I 70 East: Hagerstown | 600 feet | |
| Keep left towards I 70 East: Hagerstown | 0.4 mi | |
| Merge left onto Dwight David Eisenhower Highway (I 70) | 600 feet | |
| Continue onto Dwight D Eisenhower Highway (I 70) | 4.7 mi | |
| Continue onto I 70, US 40 (Dwight D Eisenhower Highway) (I 70) | 3.2 mi | |
| Continue onto Dwight D Eisenhower Highway (I 70) | 16.2 mi | |
| Take the ramp towards I 81: Roanoke | 600 feet | |
| Keep right towards I 81 South: Roanoke | 0.5 mi | |
| Merge left onto Maryland Veterans Memorial Highway (I 81 S) | 23.9 mi | |
| Take the ramp towards WV 51: Inwood | 0.2 mi | |
| Turn right onto Gerrardstown Road (WV 51) | 2.7 mi | |
| Turn left onto Dominion Road (CR 51/2) | 100 feet | |
| You have arrived at your destination |
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Uniontown, PA, USA - Gerrardstown, WV, USA