University of North Alabama Highway, US 72
349.9 mi6 hours 18 mins
| Head west on Blocton Bypass | 1.2 mi | |
| Turn right onto AL 5 | 7.5 mi | |
| Turn right onto US 11 | 2.9 mi | |
| Go straight | 500 feet | |
| Take the ramp on the right | 0.3 mi | |
| Merge left onto I 20 | 27.2 mi | |
| Take the ramp on the left towards I 65 North: Huntsville | 0.2 mi | |
| Merge right onto I 65 N | 49.2 mi | |
| Take exit 310 towards 157: Cullman | 0.2 mi | |
| Keep left at the fork | 100 feet | |
| Turn left onto Section Line Road (AL 157) | 200 feet | |
| Continue onto University of North Alabama Highway (AL 157) | 55.4 mi | |
| Merge right onto Wheeler Highway (US 72 Alternate) | 58.0 mi | |
| Take the ramp | 200 feet | |
| Continue onto MS 2 E | 9.1 mi | |
| Continue onto US 45 | 7.5 mi | |
| Turn left onto Marcus J Wright Memorial (US 45) | 36.1 mi | |
| Continue onto S Highland Ave (US 45) | 1.6 mi | |
| Continue onto South Highland Avenue (US 45) | 0.7 mi | |
| Turn left onto West Chester Street (US 45 Bypass) | 11.5 mi | |
| Take the ramp onto US 45E | 43.0 mi | |
| Take the ramp | 0.2 mi | |
| Merge left onto US 45E S | 500 feet | |
| Continue onto Skyhawk Parkway (TN 43 N) | 6.8 mi | |
| Turn left onto US 45E | 8.0 mi | |
| Continue onto US 51 N | 1.4 mi | |
| Take the ramp onto US 51 N | 0.3 mi | |
| Turn left onto Nolan Avenue (US 51) | 21.2 mi | |
| You have arrived at your destination |
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West Blocton, Alabama - Arlington, Kentucky