I 95 $south, I 295
598.4 mi9 hours 11 mins
| Head southwest on Owensville Road (MD 255) | 0.5 mi | |
| Turn left onto Solomons Island Road (MD 2) | 1.3 mi | |
| Enter the roundabout and take the 2nd exit onto Marlboro Road (MD 408) | 100 feet | |
| Exit the roundabout onto Marlboro Road (MD 408) | 5.5 mi | |
| Take the ramp towards MD 4 North: Upper Marlboro | 0.4 mi | |
| Merge left onto Stephanie Roper Highway (MD 4) | 2.2 mi | |
| Continue onto Pennsylvania Avenue (MD 4) | 7.3 mi | |
| Take the ramp towards I 95 South: Richmond Virginia | 0.3 mi | |
| Merge left onto Capital Beltway (I 95 S) | 7.1 mi | |
| Keep left towards I 95 Express | 2.5 mi | |
| Continue onto Woodrow Wilson Memorial Bridge (Express) (I 95) | 0.6 mi | |
| Continue onto Woodrow Wilson Bridge (Express) (I 95) | 0.5 mi | |
| Continue onto Capital Beltway (Express) (I 95) | 2.9 mi | |
| Merge right onto Capital Beltway (I 95 S) | 2.9 mi | |
| Keep left onto I 95 S | 86.0 mi | |
| Take the ramp on the left towards I 295 South: Rocky Mount NC | 1.8 mi | |
| Merge right onto I 295 | 42.4 mi | |
| Merge right towards I 95 South: Emporia | 418.5 mi | |
| Take the ramp towards US 278: Hardeeville | 0.2 mi | |
| Keep left towards US 278 East: Sun City | 300 feet | |
| Continue left onto Independence Boulevard (US 278) | 6.3 mi | |
| Continue onto Fording Island Road (US 278) | 7.4 mi | |
| Turn right onto Bluffton Road (SC 46) | 0.8 mi | |
| Enter the roundabout and take the 2nd exit onto Bluffton Road (SC 46) | 200 feet | |
| Exit the roundabout onto Bluffton Road (SC 46) | 0.9 mi | |
| Turn left onto Bruin Road | 0 feet | |
| You have arrived at your destination |
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West River, Maryland - Bluffton, South Carolina